Drosophila Stem Cells Share a Common Requirement for the Histone H2B Ubiquitin Protease Scrawny Export

@article{citeulike:3884583, abstract = {Stem cells within diverse tissues share the need for a chromatin configuration that promotes self-renewal, yet few chromatin proteins are known to regulate multiple types of stem cells. We describe a Drosophila gene, scrawny (scny), encoding a ubiquitin-specific protease, which is required in germline, epithelial, and intestinal stem cells. Like its yeast relative UBP10, Scrawny deubiquitylates histone H2B and functions in gene silencing. Consistent with previous studies of this conserved pathway of chromatin regulation, scny mutant cells have elevated levels of ubiquitinylated H2B and trimethylated H3K4. Our findings suggest that inhibiting H2B ubiquitylation through scny represents a common mechanism within stem cells that is used to repress the premature expression of key differentiation genes, including Notch target genes. 10.1126/science.1165678}, author = {Buszczak, Michael and Paterno, Shelley and Spradling, Allan C.}, citeulike-article-id = {3884583}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1165678}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/323/5911/248}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19039105}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19039105}, day = {9}, doi = {10.1126/science.1165678}, journal = {Science}, keywords = {chromatin, epigenetics, histone}, month = {January}, number = {5911}, pages = {248--251}, posted-at = {2009-01-14 09:18:58}, priority = {2}, title = {Drosophila Stem Cells Share a Common Requirement for the Histone H2B Ubiquitin Protease Scrawny}, url = {http://dx.doi.org/10.1126/science.1165678}, volume = {323}, year = {2009} }

TY - JOUR ID - citeulike:3884583 L3 - citeulike-article-id:3884583 N2 - Stem cells within diverse tissues share the need for a chromatin configuration that promotes self-renewal, yet few chromatin proteins are known to regulate multiple types of stem cells. We describe a Drosophila gene, scrawny (scny), encoding a ubiquitin-specific protease, which is required in germline, epithelial, and intestinal stem cells. Like its yeast relative UBP10, Scrawny deubiquitylates histone H2B and functions in gene silencing. Consistent with previous studies of this conserved pathway of chromatin regulation, scny mutant cells have elevated levels of ubiquitinylated H2B and trimethylated H3K4. Our findings suggest that inhibiting H2B ubiquitylation through scny represents a common mechanism within stem cells that is used to repress the premature expression of key differentiation genes, including Notch target genes. 10.1126/science.1165678 IS - 5911 JF - Science EP - 251 TI - Drosophila Stem Cells Share a Common Requirement for the Histone H2B Ubiquitin Protease Scrawny VL - 323 SP - 248 KW - chromatin KW - epigenetics KW - histone AU - Buszczak, Michael AU - Paterno, Shelley AU - Spradling, Allan PY - 2009/01/09/ UR - http://dx.doi.org/10.1126/science.1165678 ER -