The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women Export

@article{citeulike:1592519, abstract = {Abstract Summary\ \ BMD and clinical risk factors predict hip and other osteoporotic fractures. The combination of clinical risk factors and BMD provide higher specificity and sensitivity than either alone. Introduction and hypotheses\ \ To develop a risk assessment tool based on clinical risk factors (CRFs) with and without BMD. Methods\ \ Nine population-based studies were studied in which BMD and CRFs were documented at baseline. Poisson regression models were developed for hip fracture and other osteoporotic fractures, with and without hip BMD. Fracture risk was expressed as gradient of risk (GR, risk ratio/SD change in risk score). Results\ \ CRFs alone predicted hip fracture with a GR of 2.1/SD at the age of 50\ years and decreased with age. The use of BMD alone provided a higher GR (3.7/SD), and was improved further with the combined use of CRFs and BMD (4.2/SD). For other osteoporotic fractures, the GRs were lower than for hip fracture. The GR with CRFs alone was 1.4/SD at the age of 50\ years, similar to that provided by BMD (GR = 1.4/SD) and was not markedly increased by the combination (GR = 1.4/SD). The performance characteristics of clinical risk factors with and without BMD were validated in eleven independent population-based cohorts. Conclusions\ \ The models developed provide the basis for the integrated use of validated clinical risk factors in men and women to aid in fracture risk prediction.}, author = {Kanis, J. and Oden, A. and Johnell, O. and Johansson, H. and De Laet, C. and Brown, J. and Burckhardt, P. and Cooper, C. and Christiansen, C. and Cummings, S. and Eisman, J. and Fujiwara, S. and Gl\"{u}er, C. and Goltzman, D. and Hans, D. and Krieg, M. A. and La Croix, A. and Mccloskey, E. and Mellstrom, D. and Melton, L. and Pols, H. and Reeve, J. and Sanders, K. and Schott, A. M. and Silman, A. and Torgerson, D. and van Staa, T. and Watts, N. and Yoshimura, N.}, citeulike-article-id = {1592519}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s00198-007-0343-y}, citeulike-linkout-1 = {http://www.ingentaconnect.com/content/klu/198/2007/00000018/00000008/00000343}, citeulike-linkout-2 = {http://www.springerlink.com/content/707t6668115h0727}, day = {1}, doi = {10.1007/s00198-007-0343-y}, issn = {0937-941X}, journal = {Osteoporosis International}, keywords = {facteurs\_de\_risque, fracture\_osteoporotique, osteoporose}, month = {August}, number = {8}, pages = {1033--1046}, posted-at = {2008-05-23 14:19:21}, priority = {2}, publisher = {Springer}, title = {The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women}, url = {http://dx.doi.org/10.1007/s00198-007-0343-y}, volume = {18}, year = {2007} }

TY - JOUR ID - citeulike:1592519 L3 - citeulike-article-id:1592519 N2 - Abstract Summary  BMD and clinical risk factors predict hip and other osteoporotic fractures. The combination of clinical risk factors and BMD provide higher specificity and sensitivity than either alone. Introduction and hypotheses  To develop a risk assessment tool based on clinical risk factors (CRFs) with and without BMD. Methods  Nine population-based studies were studied in which BMD and CRFs were documented at baseline. Poisson regression models were developed for hip fracture and other osteoporotic fractures, with and without hip BMD. Fracture risk was expressed as gradient of risk (GR, risk ratio/SD change in risk score). Results  CRFs alone predicted hip fracture with a GR of 2.1/SD at the age of 50 years and decreased with age. The use of BMD alone provided a higher GR (3.7/SD), and was improved further with the combined use of CRFs and BMD (4.2/SD). For other osteoporotic fractures, the GRs were lower than for hip fracture. The GR with CRFs alone was 1.4/SD at the age of 50 years, similar to that provided by BMD (GR = 1.4/SD) and was not markedly increased by the combination (GR = 1.4/SD). The performance characteristics of clinical risk factors with and without BMD were validated in eleven independent population-based cohorts. Conclusions  The models developed provide the basis for the integrated use of validated clinical risk factors in men and women to aid in fracture risk prediction. IS - 8 JF - Osteoporosis International SN - 0937-941X EP - 1046 TI - The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women PB - Springer VL - 18 SP - 1033 KW - facteurs_de_risque KW - fracture_osteoporotique KW - osteoporose AU - Kanis, J AU - Oden, A AU - Johnell, O AU - Johansson, H AU - De Laet, C AU - Brown, J AU - Burckhardt, P AU - Cooper, C AU - Christiansen, C AU - Cummings, S AU - Eisman, J AU - Fujiwara, S AU - Glüer, C AU - Goltzman, D AU - Hans, D AU - Krieg, MA AU - La Croix, A AU - Mccloskey, E AU - Mellstrom, D AU - Melton, L AU - Pols, H AU - Reeve, J AU - Sanders, K AU - Schott, AM AU - Silman, A AU - Torgerson, D AU - van Staa, T AU - Watts, N AU - Yoshimura, N PY - 2007/08/01/ UR - http://dx.doi.org/10.1007/s00198-007-0343-y ER -