Low vitamin D status adversely affects bone health parameters in adolescents. Export

@article{citeulike:2901784, abstract = {BACKGROUND: The effects of subclinical vitamin D deficiency on bone mineral density (BMD) and bone turnover in adolescents, especially in boys, are unclear. OBJECTIVE: We aimed to investigate the relations of different stages of vitamin D status and BMD and bone turnover in a representative sample of adolescent boys and girls. DESIGN: BMD was measured by dual-energy X-ray absorptiometry at the nondominant forearm and dominant heel in a random sample of 12- (n = 260) and 15-y-old (n = 239) boys and 12- (n = 266) and 15-y-old (n = 250) girls. Serum 25-hydroxyvitamin D, parathyroid hormone, osteocalcin, and type I collagen cross-linked C-telopeptide were assessed by using enzyme-linked immunoassays. Relations between vitamin D status and bone health indexes were assessed by using regression modeling. RESULTS: Using multivariate regression to adjust for potential physical, lifestyle, and dietary confounding factors, we observed that 12- and 15-y-old girls with high vitamin D status (>/=74.1 nmol/L) had significantly greater forearm (but not heel) BMD (beta = 0.018; SE = 0.008; P < 0.05 for each age group) and lower serum parathyroid hormone concentrations and bone turnover markers than did those with low vitamin D status. These associations were evident in subjects sampled throughout the year and in winter only. There was no significant relation between vitamin D status and BMD in boys. CONCLUSIONS: Maintaining serum 25-hydroxyvitamin D concentrations above approximately 50 nmol/L throughout the year may be a cost-effective means of improving bone health. Increased emphasis on exploring strategies for improving vitamin D status in adolescents is needed.}, address = {Department of Food and Nutritional Sciences, University College, Western Road, Cork, Ireland. k.cashman@ucc.ie}, author = {Cashman, K. D. and Hill, T. R. and Cotter, A. A. and Boreham, C. A. and Dubitzky, W. and Murray, L. and Strain, J. and Flynn, A. and Robson, P. J. and Wallace, J. M. and Kiely, M.}, citeulike-article-id = {2901784}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/18400729}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=18400729}, issn = {0002-9165}, journal = {The American journal of clinical nutrition}, keywords = {enfant, vitamine\_d}, month = {April}, number = {4}, pages = {1039--1044}, posted-at = {2008-06-17 09:46:36}, priority = {2}, title = {Low vitamin D status adversely affects bone health parameters in adolescents.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18400729}, volume = {87}, year = {2008} }

TY - JOUR ID - citeulike:2901784 L3 - citeulike-article-id:2901784 N2 - BACKGROUND: The effects of subclinical vitamin D deficiency on bone mineral density (BMD) and bone turnover in adolescents, especially in boys, are unclear. OBJECTIVE: We aimed to investigate the relations of different stages of vitamin D status and BMD and bone turnover in a representative sample of adolescent boys and girls. DESIGN: BMD was measured by dual-energy X-ray absorptiometry at the nondominant forearm and dominant heel in a random sample of 12- (n = 260) and 15-y-old (n = 239) boys and 12- (n = 266) and 15-y-old (n = 250) girls. Serum 25-hydroxyvitamin D, parathyroid hormone, osteocalcin, and type I collagen cross-linked C-telopeptide were assessed by using enzyme-linked immunoassays. Relations between vitamin D status and bone health indexes were assessed by using regression modeling. RESULTS: Using multivariate regression to adjust for potential physical, lifestyle, and dietary confounding factors, we observed that 12- and 15-y-old girls with high vitamin D status (>/=74.1 nmol/L) had significantly greater forearm (but not heel) BMD (beta = 0.018; SE = 0.008; P < 0.05 for each age group) and lower serum parathyroid hormone concentrations and bone turnover markers than did those with low vitamin D status. These associations were evident in subjects sampled throughout the year and in winter only. There was no significant relation between vitamin D status and BMD in boys. CONCLUSIONS: Maintaining serum 25-hydroxyvitamin D concentrations above approximately 50 nmol/L throughout the year may be a cost-effective means of improving bone health. Increased emphasis on exploring strategies for improving vitamin D status in adolescents is needed. IS - 4 JF - The American journal of clinical nutrition SN - 0002-9165 AD - Department of Food and Nutritional Sciences, University College, Western Road, Cork, Ireland. k.cashman@ucc.ie EP - 1044 TI - Low vitamin D status adversely affects bone health parameters in adolescents. VL - 87 SP - 1039 KW - enfant KW - vitamine_d AU - Cashman, KD AU - Hill, TR AU - Cotter, AA AU - Boreham, CA AU - Dubitzky, W AU - Murray, L AU - Strain, J AU - Flynn, A AU - Robson, PJ AU - Wallace, JM AU - Kiely, M PY - 2008/04// UR - http://view.ncbi.nlm.nih.gov/pubmed/18400729 ER -