Genome-wide approaches to studying chromatin modifications. Export

@article{citeulike:2393920, abstract = {Over two metres of DNA is packaged into each nucleus in the human body in a manner that still allows for gene regulation. This remarkable feat is accomplished by the wrapping of DNA around histone proteins in repeating units of nucleosomes to form a structure known as chromatin. This chromatin structure is subject to various modifications that have profound influences on gene expression. Recently developed techniques to study chromatin modifications at a genome-wide scale are now allowing researchers to probe the complex components that make up epigenomes. Here we review genome-wide approaches to studying epigenomic structure and the exciting findings that have been obtained using these technologies.}, author = {Schones, Dustin E. and Zhao, Keji}, citeulike-article-id = {2393920}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2270}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2270}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18250624}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18250624}, doi = {10.1038/nrg2270}, issn = {1471-0064}, journal = {Nature reviews. Genetics}, keywords = {chromatin, regulation}, month = {March}, number = {3}, pages = {179--191}, posted-at = {2008-02-25 14:19:40}, priority = {2}, publisher = {Nature Publishing Group}, title = {Genome-wide approaches to studying chromatin modifications.}, url = {http://dx.doi.org/10.1038/nrg2270}, volume = {9}, year = {2008} }

TY - JOUR ID - citeulike:2393920 L3 - citeulike-article-id:2393920 N2 - Over two metres of DNA is packaged into each nucleus in the human body in a manner that still allows for gene regulation. This remarkable feat is accomplished by the wrapping of DNA around histone proteins in repeating units of nucleosomes to form a structure known as chromatin. This chromatin structure is subject to various modifications that have profound influences on gene expression. Recently developed techniques to study chromatin modifications at a genome-wide scale are now allowing researchers to probe the complex components that make up epigenomes. Here we review genome-wide approaches to studying epigenomic structure and the exciting findings that have been obtained using these technologies. IS - 3 JF - Nature reviews. Genetics SN - 1471-0064 EP - 191 TI - Genome-wide approaches to studying chromatin modifications. PB - Nature Publishing Group VL - 9 SP - 179 KW - chromatin KW - regulation AU - Schones, Dustin AU - Zhao, Keji PY - 2008/03// UR - http://dx.doi.org/10.1038/nrg2270 ER -