Quantitative proteomics analysis of the secretory pathway. Export

@article{citeulike:3362684, abstract = {We report more than 1400 proteins of the secretory-pathway proteome and provide spatial information on the relative presence of each protein in the rough and smooth ER Golgi cisternae and Golgi-derived COPI vesicles. The data support a role for COPI vesicles in recycling and cisternal maturation, showing that Golgi-resident proteins are present at a higher concentration than secretory cargo. Of the 1400 proteins, 345 were identified as previously uncharacterized. Of these, 230 had their subcellular location deduced by proteomics. This study provides a comprehensive catalog of the ER and Golgi proteomes with insight into their identity and function.}, author = {Gilchrist, A. and Au, C. E. and Hiding, J. and Bell, A. W. and Fernandez-Rodriguez, J. and Lesimple, S. and Nagaya, H. and Roy, L. and Gosline, S. J. and Hallett, M. and Paiement, J. and Kearney, R. E. and Nilsson, T. and Bergeron, J. J.}, citeulike-article-id = {3362684}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cell.2006.10.036}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17174899}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17174899}, day = {15}, doi = {10.1016/j.cell.2006.10.036}, issn = {0092-8674}, journal = {Cell}, keywords = {cell, coatomer, copi, copii, golgi, in\_vivo, ms, quantitative, separation, traffic, vesicle}, month = {December}, number = {6}, pages = {1265--1281}, posted-at = {2008-10-01 13:17:49}, priority = {2}, title = {Quantitative proteomics analysis of the secretory pathway.}, url = {http://dx.doi.org/10.1016/j.cell.2006.10.036}, volume = {127}, year = {2006} }

TY - JOUR ID - citeulike:3362684 L3 - citeulike-article-id:3362684 N2 - We report more than 1400 proteins of the secretory-pathway proteome and provide spatial information on the relative presence of each protein in the rough and smooth ER Golgi cisternae and Golgi-derived COPI vesicles. The data support a role for COPI vesicles in recycling and cisternal maturation, showing that Golgi-resident proteins are present at a higher concentration than secretory cargo. Of the 1400 proteins, 345 were identified as previously uncharacterized. Of these, 230 had their subcellular location deduced by proteomics. This study provides a comprehensive catalog of the ER and Golgi proteomes with insight into their identity and function. IS - 6 JF - Cell SN - 0092-8674 EP - 1281 TI - Quantitative proteomics analysis of the secretory pathway. VL - 127 SP - 1265 KW - cell KW - coatomer KW - copi KW - copii KW - golgi KW - in_vivo KW - ms KW - quantitative KW - separation KW - traffic KW - vesicle AU - Gilchrist, A AU - Au, CE AU - Hiding, J AU - Bell, AW AU - Fernandez-Rodriguez, J AU - Lesimple, S AU - Nagaya, H AU - Roy, L AU - Gosline, SJ AU - Hallett, M AU - Paiement, J AU - Kearney, RE AU - Nilsson, T AU - Bergeron, JJ PY - 2006/12/15/ UR - http://dx.doi.org/10.1016/j.cell.2006.10.036 ER -