Golgin Tethers Define Subpopulations of COPI Vesicles Export

@article{citeulike:525121, abstract = {Coiled-coil proteins of the golgin family have been implicated in intra-Golgi transport through tethering coat protein complex I (COPI) vesicles. The p115-golgin tether is the best studied, and here we characterize the golgin-84-CASP tether. The vesicles bound by this tether were strikingly different from those bound by the p115-golgin tether in that they lacked members of the p24 family of putative cargo receptors and contained enzymes instead of anterograde cargo. Microinjected golgin-84 or CASP also inhibited Golgi-enzyme transport to the endoplasmic reticulum, further implicating this tether in retrograde transport. These and other golgins may modulate the flow patterns within the Golgi stack.}, author = {Malsam, Jorg and Satoh, Ayano and Pelletier, Laurence and Warren, Graham}, citeulike-article-id = {525121}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1108061}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/307/5712/1095}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15718469}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15718469}, day = {18}, doi = {10.1126/science.1108061}, journal = {Science}, keywords = {coatomer, copi, golgi, in\_vivo, interactions, membrane, p24\_family, snare, traffic}, month = {February}, number = {5712}, pages = {1095--1098}, posted-at = {2008-12-14 22:31:25}, priority = {2}, title = {Golgin Tethers Define Subpopulations of COPI Vesicles}, url = {http://dx.doi.org/10.1126/science.1108061}, volume = {307}, year = {2005} }

TY - JOUR ID - citeulike:525121 L3 - citeulike-article-id:525121 N2 - Coiled-coil proteins of the golgin family have been implicated in intra-Golgi transport through tethering coat protein complex I (COPI) vesicles. The p115-golgin tether is the best studied, and here we characterize the golgin-84-CASP tether. The vesicles bound by this tether were strikingly different from those bound by the p115-golgin tether in that they lacked members of the p24 family of putative cargo receptors and contained enzymes instead of anterograde cargo. Microinjected golgin-84 or CASP also inhibited Golgi-enzyme transport to the endoplasmic reticulum, further implicating this tether in retrograde transport. These and other golgins may modulate the flow patterns within the Golgi stack. IS - 5712 JF - Science EP - 1098 TI - Golgin Tethers Define Subpopulations of COPI Vesicles VL - 307 SP - 1095 KW - coatomer KW - copi KW - golgi KW - in_vivo KW - interactions KW - membrane KW - p24_family KW - snare KW - traffic AU - Malsam, Jorg AU - Satoh, Ayano AU - Pelletier, Laurence AU - Warren, Graham PY - 2005/02/18/ UR - http://dx.doi.org/10.1126/science.1108061 ER -