Average protein density is a molecular-weight-dependent function. Export

@article{citeulike:543538, abstract = {The mass density of proteins is a relevant basic biophysical quantity. It is also a useful input parameter, for example, for three-dimensional structure determination by protein crystallography and studies of protein oligomers in solution by analytic ultracentrifugation. We have performed a critical analysis of published, theoretical, and experimental investigations about this issue and concluded that the average density of proteins is not a constant as often assumed. For proteins with a molecular weight below 20 kDa, the average density exhibits a positive deviation that increases for decreasing molecular weight. A simple molecular-weight-depending function is proposed that provides a more accurate estimate of the average protein density.}, address = {Institute of Physics, University of S\~{a}o Paulo, Rua do Matao Travessa R, 187 CEP 05508-900, S\~{a}o Paulo-SP, Brazil.}, author = {Fischer, H. and Polikarpov, I. and Craievich, A. F.}, citeulike-article-id = {543538}, citeulike-linkout-0 = {http://dx.doi.org/10.1110/ps.04688204}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15388866}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15388866}, citeulike-linkout-3 = {http://www3.interscience.wiley.com/cgi-bin/abstract/121602274/ABSTRACT}, doi = {10.1110/ps.04688204}, issn = {0961-8368}, journal = {Protein Sci}, keywords = {density, mass, protein}, month = {October}, number = {10}, pages = {2825--2828}, posted-at = {2008-04-16 09:50:26}, priority = {2}, title = {Average protein density is a molecular-weight-dependent function.}, url = {http://dx.doi.org/10.1110/ps.04688204}, volume = {13}, year = {2004} }

TY - JOUR ID - citeulike:543538 L3 - citeulike-article-id:543538 N2 - The mass density of proteins is a relevant basic biophysical quantity. It is also a useful input parameter, for example, for three-dimensional structure determination by protein crystallography and studies of protein oligomers in solution by analytic ultracentrifugation. We have performed a critical analysis of published, theoretical, and experimental investigations about this issue and concluded that the average density of proteins is not a constant as often assumed. For proteins with a molecular weight below 20 kDa, the average density exhibits a positive deviation that increases for decreasing molecular weight. A simple molecular-weight-depending function is proposed that provides a more accurate estimate of the average protein density. IS - 10 JF - Protein Sci SN - 0961-8368 AD - Institute of Physics, University of São Paulo, Rua do Matao Travessa R, 187 CEP 05508-900, São Paulo-SP, Brazil. EP - 2828 TI - Average protein density is a molecular-weight-dependent function. VL - 13 SP - 2825 KW - density KW - mass KW - protein AU - Fischer, H AU - Polikarpov, I AU - Craievich, AF PY - 2004/10// UR - http://dx.doi.org/10.1110/ps.04688204 ER -