The effects of cessation from cigarette smoking on the lipid and lipoprotein profiles: a meta-analysis. Export

@article{citeulike:563977, abstract = {BACKGROUND: Cross-sectional studies revealed that cigarette smokers have lower high-density lipoprotein cholesterol (HDL-C) levels and higher levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) than nonsmokers. But prospective studies on the effects of cigarette smoking cessation on lipid profile have yielded inconclusive results. METHODS: Relevant English articles were retrieved by keyword searches of MEDLINE (1966-October 2000), Cochrane Library (2000, Issue 2), and cited references. Twenty-seven studies met the following inclusion criteria: (1) prospective cohort study including clinical trials, (2) measuring smoking status and lipid profile of HDL-C, TC, LDL-C, and TG, (3) reporting the changes of lipid concentrations in abstinent smokers, and (4) not using adjuvant antihyperlipidemic drugs. RESULTS: Overall Q statistics for net change of HDL-C, TC, LDL-C, and TG showed heterogeneity. Using a random-effects model, HDL-C level increased significantly [0.100 (CI 0.074 to 0.127) mmol/L] after smoking cessation. However, levels of TC [+0.003 (CI -0.042 to 0.048)], LDL-C [-0.064 (CI -0.149 to 0.021)], and TG [+0.028 (CI -0.014 to 0.071)] did not change significantly after smoking cessation. CONCLUSIONS: Cigarette smoking cessation increases serum levels of HDL-C but not of TC, LDL-C, and TG.}, address = {Department of General Medicine and Clinical Epidemiology, Kyoto University Graduate School of Medicine, Kyoto, Japan.}, author = {Maeda, K. and Noguchi, Y. and Fukui, T.}, citeulike-article-id = {563977}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/14507483}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=14507483}, comment = {禁煙はHDL-Cを増加させるが[0.100 (CI 0.074 to 0.127) mmol/L]、その他は変化しない}, issn = {0091-7435}, journal = {Prev Med}, keywords = {cholesterol, meta-analysis, smoking}, month = {October}, number = {4}, pages = {283--290}, posted-at = {2006-03-26 16:21:30}, priority = {2}, title = {The effects of cessation from cigarette smoking on the lipid and lipoprotein profiles: a meta-analysis.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/14507483}, volume = {37}, year = {2003} }

TY - JOUR ID - citeulike:563977 L3 - citeulike-article-id:563977 N2 - BACKGROUND: Cross-sectional studies revealed that cigarette smokers have lower high-density lipoprotein cholesterol (HDL-C) levels and higher levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) than nonsmokers. But prospective studies on the effects of cigarette smoking cessation on lipid profile have yielded inconclusive results. METHODS: Relevant English articles were retrieved by keyword searches of MEDLINE (1966-October 2000), Cochrane Library (2000, Issue 2), and cited references. Twenty-seven studies met the following inclusion criteria: (1) prospective cohort study including clinical trials, (2) measuring smoking status and lipid profile of HDL-C, TC, LDL-C, and TG, (3) reporting the changes of lipid concentrations in abstinent smokers, and (4) not using adjuvant antihyperlipidemic drugs. RESULTS: Overall Q statistics for net change of HDL-C, TC, LDL-C, and TG showed heterogeneity. Using a random-effects model, HDL-C level increased significantly [0.100 (CI 0.074 to 0.127) mmol/L] after smoking cessation. However, levels of TC [+0.003 (CI -0.042 to 0.048)], LDL-C [-0.064 (CI -0.149 to 0.021)], and TG [+0.028 (CI -0.014 to 0.071)] did not change significantly after smoking cessation. CONCLUSIONS: Cigarette smoking cessation increases serum levels of HDL-C but not of TC, LDL-C, and TG. IS - 4 JF - Prev Med SN - 0091-7435 AD - Department of General Medicine and Clinical Epidemiology, Kyoto University Graduate School of Medicine, Kyoto, Japan. EP - 290 TI - The effects of cessation from cigarette smoking on the lipid and lipoprotein profiles: a meta-analysis. VL - 37 SP - 283 KW - cholesterol KW - meta-analysis KW - smoking N1 - 禁煙はHDL-Cを増加させるが[0.100 (CI 0.074 to 0.127) mmol/L]、その他は変化しない AU - Maeda, K AU - Noguchi, Y AU - Fukui, T PY - 2003/10// UR - http://view.ncbi.nlm.nih.gov/pubmed/14507483 ER -