Prevalence and antimicrobial susceptibility of Escherichia coli in outpatient urinary isolates in Izmir, Turkey. Export

@article{citeulike:6052061, abstract = {BACKGROUND: Knowledge of antimicrobial resistance pattern in Escherichia coli, the predominant pathogen associated with urinary tract infection (UTI), is important as a guide in selecting empirical antimicrobial therapy. The aim of this study was to determine the antibiotic susceptibility patterns of E. coli strains isolated from adult outpatients with UTI, in Izmir, Turkey. MATERIAL/METHODS: This study was performed with isolates from outpatients with UTI, collected from 5 university and tertiary-care hospitals in Izmir, Turkey. Isolates were analyzed by standard methods and antimicrobial susceptibility testing was performed by Kirby-Bauer disc diffusion method. RESULTS: A total of 4,534 E. coli strains (3,449 females and 1,085 males) were examined. Antibiotic resistance rates of the isolates for female and male, respectively: Ampicillin (61.8\%, 78.7\%), amoxicillin-clavulanic acid (36.6\%, 59.1\%), cefuroxime (22.5\%, 41.3\%), cefotaxime (18.2\%, 35.8\%), piperacillin-tazobactam (11.6\%, 31.2\%), amikacin (8.3\%, 13.9\%), gentamicin (24.9\%, 40\%), trimethoprim-sulfamethoxazole (42.1\%, 57.3\%), and ciprofloxacin/norfloxacin (42.1\%, 63.3\%). Extended spectrum beta-lactamase rate was found to be 18.3\% and 26.1\% for females and males, respectively. The isolates were significantly more resistant to all antibiotics in men than in females in this study (p<0.001). CONCLUSIONS: The most important finding of our study is that a considerable proportion of the studied E. coli isolates were resistant to most antibiotics except amikacin. These data provide useful information for clinicians in determining the appropriate empirical antimicrobial regimen, and help authorities to formulate antibiotic prescription policies.}, author = {Yilmaz, Nisel and Agus, Neval and Yurtsever, Sureyya Gul G. and Pullukcu, Husnu and Gulay, Zeynep and Coskuner, Ayten and Kose, Sukran and Aydemir, Sohret and Gulenc, Nalan and Ozgenc, Onur}, citeulike-article-id = {6052061}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/19865064}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=19865064}, issn = {1643-3750}, journal = {Medical science monitor : international medical journal of experimental and clinical research}, keywords = {2ee3lab3}, month = {November}, number = {11}, posted-at = {2009-10-31 23:03:53}, priority = {2}, title = {Prevalence and antimicrobial susceptibility of Escherichia coli in outpatient urinary isolates in Izmir, Turkey.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/19865064}, volume = {15}, year = {2009} }

TY - JOUR ID - citeulike:6052061 L3 - citeulike-article-id:6052061 N2 - BACKGROUND: Knowledge of antimicrobial resistance pattern in Escherichia coli, the predominant pathogen associated with urinary tract infection (UTI), is important as a guide in selecting empirical antimicrobial therapy. The aim of this study was to determine the antibiotic susceptibility patterns of E. coli strains isolated from adult outpatients with UTI, in Izmir, Turkey. MATERIAL/METHODS: This study was performed with isolates from outpatients with UTI, collected from 5 university and tertiary-care hospitals in Izmir, Turkey. Isolates were analyzed by standard methods and antimicrobial susceptibility testing was performed by Kirby-Bauer disc diffusion method. RESULTS: A total of 4,534 E. coli strains (3,449 females and 1,085 males) were examined. Antibiotic resistance rates of the isolates for female and male, respectively: Ampicillin (61.8%, 78.7%), amoxicillin-clavulanic acid (36.6%, 59.1%), cefuroxime (22.5%, 41.3%), cefotaxime (18.2%, 35.8%), piperacillin-tazobactam (11.6%, 31.2%), amikacin (8.3%, 13.9%), gentamicin (24.9%, 40%), trimethoprim-sulfamethoxazole (42.1%, 57.3%), and ciprofloxacin/norfloxacin (42.1%, 63.3%). Extended spectrum beta-lactamase rate was found to be 18.3% and 26.1% for females and males, respectively. The isolates were significantly more resistant to all antibiotics in men than in females in this study (p<0.001). CONCLUSIONS: The most important finding of our study is that a considerable proportion of the studied E. coli isolates were resistant to most antibiotics except amikacin. These data provide useful information for clinicians in determining the appropriate empirical antimicrobial regimen, and help authorities to formulate antibiotic prescription policies. IS - 11 JF - Medical science monitor : international medical journal of experimental and clinical research SN - 1643-3750 TI - Prevalence and antimicrobial susceptibility of Escherichia coli in outpatient urinary isolates in Izmir, Turkey. VL - 15 KW - 2ee3lab3 AU - Yilmaz, Nisel AU - Agus, Neval AU - Yurtsever, Sureyya Gul AU - Pullukcu, Husnu AU - Gulay, Zeynep AU - Coskuner, Ayten AU - Kose, Sukran AU - Aydemir, Sohret AU - Gulenc, Nalan AU - Ozgenc, Onur PY - 2009/11// UR - http://view.ncbi.nlm.nih.gov/pubmed/19865064 ER -