Persistent activity and the single-cell frequency-current curve in a cortical network model. Export

@article{citeulike:5973663, abstract = {Neurophysiological experiments indicate that working memory of an object is maintained by the persistent activity of cells in the prefrontal cortex and infero-temporal cortex of the monkey. This paper considers a cortical network model in which this persistent activity appears due to recurrent synaptic interactions. The conditions under which the magnitude of spontaneous and persistent activity are close to one another (as is found empirically) are investigated using a simplified mean-field description in which firing rates in these states are given by the intersections of a straight line with the f-I curve of a single pyramidal cell. The present analysis relates a network phenomenon - persistent activity in a 'working memory' state - to single-cell data which are accessible to experiment. It predicts that, in networks of the cerebral cortex in which persistent activity phenomena are observed, average synaptic inputs in both spontaneous and persistent activity should bring the cells close to firing threshold. Cells should be slightly sub-threshold in spontaneous activity, and slightly supra-threshold in persistent activity. The results are shown to be robust to the inclusion of inhomogeneities that produce wide distributions of firing rates, in both spontaneous and working memory states.}, author = {Brunel, N.}, citeulike-article-id = {5973663}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11128167}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11128167}, issn = {0954-898X}, journal = {Network (Bristol, England)}, keywords = {attractors, mean\_field, network\_dynamics, spontaneous\_activity, working\_memory}, month = {November}, number = {4}, pages = {261--280}, posted-at = {2009-10-20 12:38:03}, priority = {2}, title = {Persistent activity and the single-cell frequency-current curve in a cortical network model.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11128167}, volume = {11}, year = {2000} }

TY - JOUR ID - citeulike:5973663 L3 - citeulike-article-id:5973663 N2 - Neurophysiological experiments indicate that working memory of an object is maintained by the persistent activity of cells in the prefrontal cortex and infero-temporal cortex of the monkey. This paper considers a cortical network model in which this persistent activity appears due to recurrent synaptic interactions. The conditions under which the magnitude of spontaneous and persistent activity are close to one another (as is found empirically) are investigated using a simplified mean-field description in which firing rates in these states are given by the intersections of a straight line with the f-I curve of a single pyramidal cell. The present analysis relates a network phenomenon - persistent activity in a 'working memory' state - to single-cell data which are accessible to experiment. It predicts that, in networks of the cerebral cortex in which persistent activity phenomena are observed, average synaptic inputs in both spontaneous and persistent activity should bring the cells close to firing threshold. Cells should be slightly sub-threshold in spontaneous activity, and slightly supra-threshold in persistent activity. The results are shown to be robust to the inclusion of inhomogeneities that produce wide distributions of firing rates, in both spontaneous and working memory states. IS - 4 JF - Network (Bristol, England) SN - 0954-898X EP - 280 TI - Persistent activity and the single-cell frequency-current curve in a cortical network model. VL - 11 SP - 261 KW - attractors KW - mean_field KW - network_dynamics KW - spontaneous_activity KW - working_memory AU - Brunel, N PY - 2000/11// UR - http://view.ncbi.nlm.nih.gov/pubmed/11128167 ER -