The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Export

@article{citeulike:310727, abstract = {During performance of attention-demanding cognitive tasks, certain regions of the brain routinely increase activity, whereas others routinely decrease activity. In this study, we investigate the extent to which this task-related dichotomy is represented intrinsically in the resting human brain through examination of spontaneous fluctuations in the functional MRI blood oxygen level-dependent signal. We identify two diametrically opposed, widely distributed brain networks on the basis of both spontaneous correlations within each network and anticorrelations between networks. One network consists of regions routinely exhibiting task-related activations and the other of regions routinely exhibiting task-related deactivations. This intrinsic organization, featuring the presence of anticorrelated networks in the absence of overt task performance, provides a critical context in which to understand brain function. We suggest that both task-driven neuronal responses and behavior are reflections of this dynamic, ongoing, functional organization of the brain.}, address = {Department of Radiology, Washington University, St. Louis, MO 63110, USA. foxm@npg.wustl.edu}, author = {Fox, M. D. and Snyder, A. Z. and Vincent, J. L. and Corbetta, M. and Van Essen, D. C. and Raichle, M. E.}, citeulike-article-id = {310727}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0504136102}, citeulike-linkout-1 = {http://www.pnas.org/cgi/content/abstract/102/27/9673}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15976020}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15976020}, day = {5}, doi = {10.1073/pnas.0504136102}, issn = {0027-8424}, journal = {Proc Natl Acad Sci U S A}, keywords = {deactivation, fmri, networks}, month = {July}, number = {27}, pages = {9673--9678}, posted-at = {2008-05-30 13:30:32}, priority = {2}, title = {The human brain is intrinsically organized into dynamic, anticorrelated functional networks.}, url = {http://dx.doi.org/10.1073/pnas.0504136102}, volume = {102}, year = {2005} }

TY - JOUR ID - citeulike:310727 L3 - citeulike-article-id:310727 N2 - During performance of attention-demanding cognitive tasks, certain regions of the brain routinely increase activity, whereas others routinely decrease activity. In this study, we investigate the extent to which this task-related dichotomy is represented intrinsically in the resting human brain through examination of spontaneous fluctuations in the functional MRI blood oxygen level-dependent signal. We identify two diametrically opposed, widely distributed brain networks on the basis of both spontaneous correlations within each network and anticorrelations between networks. One network consists of regions routinely exhibiting task-related activations and the other of regions routinely exhibiting task-related deactivations. This intrinsic organization, featuring the presence of anticorrelated networks in the absence of overt task performance, provides a critical context in which to understand brain function. We suggest that both task-driven neuronal responses and behavior are reflections of this dynamic, ongoing, functional organization of the brain. IS - 27 JF - Proc Natl Acad Sci U S A SN - 0027-8424 AD - Department of Radiology, Washington University, St. Louis, MO 63110, USA. foxm@npg.wustl.edu EP - 9678 TI - The human brain is intrinsically organized into dynamic, anticorrelated functional networks. VL - 102 SP - 9673 KW - deactivation KW - fmri KW - networks AU - Fox, MD AU - Snyder, AZ AU - Vincent, JL AU - Corbetta, M AU - Van Essen, DC AU - Raichle, ME PY - 2005/07/05/ UR - http://dx.doi.org/10.1073/pnas.0504136102 ER -