MicroRNA target site polymorphisms and human disease. Export

@article{citeulike:3721896, abstract = {MicroRNAs (miRNAs) are important regulators of eukaryotic gene expression. They have been implicated in a broad range of biological processes, and miRNA-related genetic alterations probably underlie more human diseases than currently appreciated. Several studies have identified genetic variants in miRNA target sites that are claimed to be associated with disorders ranging from Parkinson's disease to cancer. However, careful assessment of these studies indicates that very few provide a combination of rigorous genetic and functional evidence. We therefore suggest a set of concrete recommendations to guide future investigations. Specifically, we highlight the importance of unbiased association studies and follow-up functional experiments for providing a clearer picture of the extent to which microRNA target site variations are relevant in various human diseases.}, author = {Sethupathy, Praveen and Collins, Francis S.}, citeulike-article-id = {3721896}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tig.2008.07.004}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0168952508002217}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18778868}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18778868}, doi = {10.1016/j.tig.2008.07.004}, issn = {0168-9525}, journal = {Trends in genetics : TIG}, keywords = {mirna, mirna\_targets, review, snp}, month = {October}, number = {10}, pages = {489--497}, posted-at = {2009-01-10 17:06:18}, priority = {2}, title = {MicroRNA target site polymorphisms and human disease.}, url = {http://dx.doi.org/10.1016/j.tig.2008.07.004}, volume = {24}, year = {2008} }

TY - JOUR ID - citeulike:3721896 L3 - citeulike-article-id:3721896 N2 - MicroRNAs (miRNAs) are important regulators of eukaryotic gene expression. They have been implicated in a broad range of biological processes, and miRNA-related genetic alterations probably underlie more human diseases than currently appreciated. Several studies have identified genetic variants in miRNA target sites that are claimed to be associated with disorders ranging from Parkinson's disease to cancer. However, careful assessment of these studies indicates that very few provide a combination of rigorous genetic and functional evidence. We therefore suggest a set of concrete recommendations to guide future investigations. Specifically, we highlight the importance of unbiased association studies and follow-up functional experiments for providing a clearer picture of the extent to which microRNA target site variations are relevant in various human diseases. IS - 10 JF - Trends in genetics : TIG SN - 0168-9525 EP - 497 TI - MicroRNA target site polymorphisms and human disease. VL - 24 SP - 489 KW - mirna KW - mirna_targets KW - review KW - snp AU - Sethupathy, Praveen AU - Collins, Francis PY - 2008/10// UR - http://dx.doi.org/10.1016/j.tig.2008.07.004 ER -