Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc. Export

@article{citeulike:3873332, abstract = {Adenovirus E1A drives oncogenesis by targeting key regulatory pathways that are critical for cellular growth control. The interaction of E1A with p400 is essential for many E1A activities, but the downstream target of this interaction is unknown. Here, we present evidence that the oncoprotein transcription factor Myc is the target of this interaction. We show that E1A stabilizes Myc protein via p400 and promotes the coassociation of Myc and p400 at Myc target genes, leading to their transcriptional induction. We also show that E1A requires Myc for its ability to activate Myc-dependent gene expression and induce apoptosis, and that forced expression of Myc is sufficient to rescue the activity of an E1A-mutant defective in p400 binding. Together, these findings establish that Myc, via p400, is an essential downstream target of E1A.}, author = {Tworkowski, K. A. and Chakraborty, A. A. and Samuelson, A. V. and Seger, Y. R. and Narita, M. and Hannon, G. J. and Lowe, S. W. and Tansey, W. P.}, citeulike-article-id = {3873332}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0802095105}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18413597}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18413597}, day = {22}, doi = {10.1073/pnas.0802095105}, issn = {1091-6490}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {e1a, myc, p400, transcriptional\_regulation}, month = {April}, number = {16}, pages = {6103--6108}, posted-at = {2009-01-10 17:40:54}, priority = {2}, title = {Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc.}, url = {http://dx.doi.org/10.1073/pnas.0802095105}, volume = {105}, year = {2008} }

TY - JOUR ID - citeulike:3873332 L3 - citeulike-article-id:3873332 N2 - Adenovirus E1A drives oncogenesis by targeting key regulatory pathways that are critical for cellular growth control. The interaction of E1A with p400 is essential for many E1A activities, but the downstream target of this interaction is unknown. Here, we present evidence that the oncoprotein transcription factor Myc is the target of this interaction. We show that E1A stabilizes Myc protein via p400 and promotes the coassociation of Myc and p400 at Myc target genes, leading to their transcriptional induction. We also show that E1A requires Myc for its ability to activate Myc-dependent gene expression and induce apoptosis, and that forced expression of Myc is sufficient to rescue the activity of an E1A-mutant defective in p400 binding. Together, these findings establish that Myc, via p400, is an essential downstream target of E1A. IS - 16 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 1091-6490 EP - 6108 TI - Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc. VL - 105 SP - 6103 KW - e1a KW - myc KW - p400 KW - transcriptional_regulation AU - Tworkowski, KA AU - Chakraborty, AA AU - Samuelson, AV AU - Seger, YR AU - Narita, M AU - Hannon, GJ AU - Lowe, SW AU - Tansey, WP PY - 2008/04/22/ UR - http://dx.doi.org/10.1073/pnas.0802095105 ER -