DNA methylation profiles in monozygotic and dizygotic twins Export

@article{citeulike:3919802, abstract = {Twin studies have provided the basis for genetic and epidemiological studies in human complex traits. As epigenetic factors can contribute to phenotypic outcomes, we conducted a DNA methylation analysis in white blood cells (WBC), buccal epithelial cells and gut biopsies of 114 monozygotic (MZ) twins as well as WBC and buccal epithelial cells of 80 dizygotic (DZ) twins using 12K CpG island microarrays. Here we provide the first annotation of epigenetic metastability of approximately 6,000 unique genomic regions in MZ twins. An intraclass correlation (ICC)-based comparison of matched MZ and DZ twins showed significantly higher epigenetic difference in buccal cells of DZ co-twins (P = 1.2 x 10(-294)). Although such higher epigenetic discordance in DZ twins can result from DNA sequence differences, our in silico SNP analyses and animal studies favor the hypothesis that it is due to epigenomic differences in the zygotes, suggesting that molecular mechanisms of heritability may not be limited to DNA sequence differences.}, author = {Kaminsky, Zachary A. and Tang, Thomas and Wang, Sun-Chong and Ptak, Carolyn and Oh, Gabriel H. T. and Wong, Albert H. C. and Feldcamp, Laura A. and Virtanen, Carl and Halfvarson, Jonas and Tysk, Curt and McRae, Allan F. and Visscher, Peter M. and Montgomery, Grant W. and Gottesman, Irving I. and Martin, Nicholas G. and Petronis, Art}, citeulike-article-id = {3919802}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ng.286}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ng.286}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19151718}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19151718}, day = {18}, doi = {10.1038/ng.286}, issn = {1546-1718}, journal = {Nat Genet}, keywords = {dna\_methylation}, month = {January}, number = {2}, pages = {240--245}, posted-at = {2009-02-08 15:50:41}, priority = {2}, publisher = {Nature Publishing Group}, title = {DNA methylation profiles in monozygotic and dizygotic twins}, url = {http://dx.doi.org/10.1038/ng.286}, volume = {41}, year = {2009} }

TY - JOUR ID - citeulike:3919802 L3 - citeulike-article-id:3919802 N2 - Twin studies have provided the basis for genetic and epidemiological studies in human complex traits. As epigenetic factors can contribute to phenotypic outcomes, we conducted a DNA methylation analysis in white blood cells (WBC), buccal epithelial cells and gut biopsies of 114 monozygotic (MZ) twins as well as WBC and buccal epithelial cells of 80 dizygotic (DZ) twins using 12K CpG island microarrays. Here we provide the first annotation of epigenetic metastability of approximately 6,000 unique genomic regions in MZ twins. An intraclass correlation (ICC)-based comparison of matched MZ and DZ twins showed significantly higher epigenetic difference in buccal cells of DZ co-twins (P = 1.2 x 10(-294)). Although such higher epigenetic discordance in DZ twins can result from DNA sequence differences, our in silico SNP analyses and animal studies favor the hypothesis that it is due to epigenomic differences in the zygotes, suggesting that molecular mechanisms of heritability may not be limited to DNA sequence differences. IS - 2 JF - Nat Genet SN - 1546-1718 EP - 245 TI - DNA methylation profiles in monozygotic and dizygotic twins PB - Nature Publishing Group VL - 41 SP - 240 KW - dna_methylation AU - Kaminsky, Zachary AU - Tang, Thomas AU - Wang, Sun-Chong AU - Ptak, Carolyn AU - Oh, Gabriel AU - Wong, Albert AU - Feldcamp, Laura AU - Virtanen, Carl AU - Halfvarson, Jonas AU - Tysk, Curt AU - McRae, Allan AU - Visscher, Peter AU - Montgomery, Grant AU - Gottesman, Irving AU - Martin, Nicholas AU - Petronis, Art PY - 2009/01/18/ UR - http://dx.doi.org/10.1038/ng.286 ER -