Cross-reactive memory CD8(+) T cells alter the immune response to heterologous secondary dengue virus infections in mice in a sequence-specific manner. Export

@article{citeulike:2705983, abstract = {Dengue virus is the causative agent of dengue fever and the more-severe dengue hemorrhagic fever (DHF). Human studies suggest that the increased risk of DHF during secondary infection is due to immunopathology partially mediated by cross-reactive memory T cells from the primary infection. To model T cell responses to sequential infections, we immunized mice with different sequences of dengue virus serotypes and measured the frequency of peptide-specific T cells after infection. The acute response after heterologous secondary infections was enhanced compared with the acute or memory response after primary infection. Also, the hierarchy of epitope-specific responses was influenced by the specific sequence of infection. Adoptive-transfer experiments showed that memory T cells responded preferentially to the secondary infection. These findings demonstrate that cross-reactive T cells from a primary infection alter the immune response during a heterologous secondary infection.}, address = {Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA.}, author = {Beaumier, C. M. and Mathew, A. and Bashyam, H. S. and Rothman, A. L.}, citeulike-article-id = {2705983}, citeulike-linkout-0 = {http://dx.doi.org/10.1086/526790}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18275279}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18275279}, citeulike-linkout-3 = {http://www.journals.uchicago.edu/doi/abs/10.1086/526790}, day = {15}, doi = {10.1086/526790}, issn = {0022-1899}, journal = {The Journal of infectious diseases}, keywords = {cd8, dengue, immune}, month = {February}, number = {4}, pages = {608--617}, posted-at = {2009-06-16 02:59:18}, priority = {2}, title = {Cross-reactive memory CD8(+) T cells alter the immune response to heterologous secondary dengue virus infections in mice in a sequence-specific manner.}, url = {http://dx.doi.org/10.1086/526790}, volume = {197}, year = {2008} }

TY - JOUR ID - citeulike:2705983 L3 - citeulike-article-id:2705983 N2 - Dengue virus is the causative agent of dengue fever and the more-severe dengue hemorrhagic fever (DHF). Human studies suggest that the increased risk of DHF during secondary infection is due to immunopathology partially mediated by cross-reactive memory T cells from the primary infection. To model T cell responses to sequential infections, we immunized mice with different sequences of dengue virus serotypes and measured the frequency of peptide-specific T cells after infection. The acute response after heterologous secondary infections was enhanced compared with the acute or memory response after primary infection. Also, the hierarchy of epitope-specific responses was influenced by the specific sequence of infection. Adoptive-transfer experiments showed that memory T cells responded preferentially to the secondary infection. These findings demonstrate that cross-reactive T cells from a primary infection alter the immune response during a heterologous secondary infection. IS - 4 JF - The Journal of infectious diseases SN - 0022-1899 AD - Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA. EP - 617 TI - Cross-reactive memory CD8(+) T cells alter the immune response to heterologous secondary dengue virus infections in mice in a sequence-specific manner. VL - 197 SP - 608 KW - cd8 KW - dengue KW - immune AU - Beaumier, CM AU - Mathew, A AU - Bashyam, HS AU - Rothman, AL PY - 2008/02/15/ UR - http://dx.doi.org/10.1086/526790 ER -