Relationship of Preexisting Dengue Virus (DV) Neutralizing Antibody Levels to Viremia and Severity of Disease in a Prospective Cohort Study of DV Infection in Thailand Export

@article{citeulike:5790586, abstract = {doi: 10.1086/382280 PMID: 14999601 Background.  Infection with any 1 of the 4 dengue viruses (DVs) can produce several illnesses, ranging from a mild febrile illness to classic dengue fever (DF) to dengue hemorrhagic fever (DHF), a potentially life‐threatening disease. Most DHF cases occur after sequential heterotypic DV infections. The role of preexisting humoral immunity in modifying severity of dengue disease is not well understood. Methods.  We conducted a prospective cohort study of children in a region where dengue disease is hyperendemic and examined the role of preexisting neutralizing anti‐DV antibodies (Abs) in modifying secondary dengue‐3 virus (D3V), dengue‐2 virus (D2V), and dengue‐1 virus (D1V) infections. Results.  In secondary D3V infection, higher levels of preexisting neutralizing Ab directed against D3V (reference virus strain and patient's virus isolate) were associated with lower viremia levels and milder disease. Preexisting neutralizing Ab levels against D2V were not associated with severity of secondary D2V infection. The levels of preexisting neutralizing Ab against the infecting virus isolates were not associated with viremia levels in secondary D2V or D1V infections. Conclusions.  Cross‐reactive memory humoral immune responses appear to be beneficial in symptomatic secondary D3V infection, but not in secondary D2V or D1V infection. These results may have important implications for the development of live attenuated tetravalent dengue vaccines.}, author = {Endy, Timothy P. and Nisalak, Ananda and Chunsuttitwat, Supamit and Vaughn, David W. and Green, Sharone and Ennis, Francis A. and Rothman, Alan L. and Libraty, Daniel H.}, citeulike-article-id = {5790586}, citeulike-linkout-0 = {http://dx.doi.org/10.1086/382280}, citeulike-linkout-1 = {http://www.journals.uchicago.edu/doi/abs/10.1086/382280}, day = {15}, doi = {10.1086/382280}, journal = {The Journal of Infectious Diseases}, keywords = {antibody, dengue, disease, neutralization}, month = {March}, number = {6}, pages = {990--1000}, posted-at = {2009-09-16 07:14:32}, priority = {2}, title = {Relationship of Preexisting Dengue Virus (DV) Neutralizing Antibody Levels to Viremia and Severity of Disease in a Prospective Cohort Study of DV Infection in Thailand}, url = {http://dx.doi.org/10.1086/382280}, volume = {189}, year = {2004} }

TY - JOUR ID - citeulike:5790586 L3 - citeulike-article-id:5790586 N2 - doi: 10.1086/382280 PMID: 14999601 Background.  Infection with any 1 of the 4 dengue viruses (DVs) can produce several illnesses, ranging from a mild febrile illness to classic dengue fever (DF) to dengue hemorrhagic fever (DHF), a potentially life‐threatening disease. Most DHF cases occur after sequential heterotypic DV infections. The role of preexisting humoral immunity in modifying severity of dengue disease is not well understood. Methods.  We conducted a prospective cohort study of children in a region where dengue disease is hyperendemic and examined the role of preexisting neutralizing anti‐DV antibodies (Abs) in modifying secondary dengue‐3 virus (D3V), dengue‐2 virus (D2V), and dengue‐1 virus (D1V) infections. Results.  In secondary D3V infection, higher levels of preexisting neutralizing Ab directed against D3V (reference virus strain and patient’s virus isolate) were associated with lower viremia levels and milder disease. Preexisting neutralizing Ab levels against D2V were not associated with severity of secondary D2V infection. The levels of preexisting neutralizing Ab against the infecting virus isolates were not associated with viremia levels in secondary D2V or D1V infections. Conclusions.  Cross‐reactive memory humoral immune responses appear to be beneficial in symptomatic secondary D3V infection, but not in secondary D2V or D1V infection. These results may have important implications for the development of live attenuated tetravalent dengue vaccines. IS - 6 JF - The Journal of Infectious Diseases EP - 1000 TI - Relationship of Preexisting Dengue Virus (DV) Neutralizing Antibody Levels to Viremia and Severity of Disease in a Prospective Cohort Study of DV Infection in Thailand VL - 189 SP - 990 KW - antibody KW - dengue KW - disease KW - neutralization AU - Endy, Timothy AU - Nisalak, Ananda AU - Chunsuttitwat, Supamit AU - Vaughn, David AU - Green, Sharone AU - Ennis, Francis AU - Rothman, Alan AU - Libraty, Daniel PY - 2004/03/15/ UR - http://dx.doi.org/10.1086/382280 ER -