Structure of dengue virus: implications for flavivirus organization, maturation, and fusion. Export

@article{citeulike:927184, abstract = {The first structure of a flavivirus has been determined by using a combination of cryoelectron microscopy and fitting of the known structure of glycoprotein E into the electron density map. The virus core, within a lipid bilayer, has a less-ordered structure than the external, icosahedral scaffold of 90 glycoprotein E dimers. The three E monomers per icosahedral asymmetric unit do not have quasiequivalent symmetric environments. Difference maps indicate the location of the small membrane protein M relative to the overlaying scaffold of E dimers. The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane.}, address = {Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA. rjkuhn@bragg.bio.purdue.edu}, author = {Kuhn, Richard J. and Zhang, Wei and Rossmann, Michael G. and Pletnev, Sergei V. and Corver, Jeroen and Lenches, Edith and Jones, Christopher T. and Mukhopadhyay, Suchetana and Chipman, Paul R. and Strauss, Ellen G. and Baker, Timothy S. and Strauss, James H.}, citeulike-article-id = {927184}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11893341}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11893341}, day = {8}, issn = {0092-8674}, journal = {Cell}, month = {March}, number = {5}, pages = {717--725}, posted-at = {2009-09-16 19:26:15}, priority = {2}, title = {Structure of dengue virus: implications for flavivirus organization, maturation, and fusion.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11893341}, volume = {108}, year = {2002} }

TY - JOUR ID - citeulike:927184 L3 - citeulike-article-id:927184 N2 - The first structure of a flavivirus has been determined by using a combination of cryoelectron microscopy and fitting of the known structure of glycoprotein E into the electron density map. The virus core, within a lipid bilayer, has a less-ordered structure than the external, icosahedral scaffold of 90 glycoprotein E dimers. The three E monomers per icosahedral asymmetric unit do not have quasiequivalent symmetric environments. Difference maps indicate the location of the small membrane protein M relative to the overlaying scaffold of E dimers. The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane. IS - 5 JF - Cell SN - 0092-8674 AD - Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA. rjkuhn@bragg.bio.purdue.edu EP - 725 TI - Structure of dengue virus: implications for flavivirus organization, maturation, and fusion. VL - 108 SP - 717 AU - Kuhn, Richard AU - Zhang, Wei AU - Rossmann, Michael AU - Pletnev, Sergei AU - Corver, Jeroen AU - Lenches, Edith AU - Jones, Christopher AU - Mukhopadhyay, Suchetana AU - Chipman, Paul AU - Strauss, Ellen AU - Baker, Timothy AU - Strauss, James PY - 2002/03/08/ UR - http://view.ncbi.nlm.nih.gov/pubmed/11893341 ER -