The origin of modern metabolic networks inferred from phylogenomic analysis of protein architecture Export

@article{citeulike:1457751, abstract = {10.1073/pnas.0701214104 Metabolism represents a complex collection of enzymatic reactions and transport processes that convert metabolites into molecules capable of supporting cellular life. Here we explore the origins and evolution of modern metabolism. Using phylogenomic information linked to the structure of metabolic enzymes, we sort out recruitment processes and discover that most enzymatic activities were associated with the nine most ancient and widely distributed protein fold architectures. An analysis of newly discovered functions showed enzymatic diversification occurred early, during the onset of the modern protein world. Most importantly, phylogenetic reconstruction exercises and other evidence suggest strongly that metabolism originated in enzymes with the P-loop hydrolase fold in nucleotide metabolism, probably in pathways linked to the purine metabolic subnetwork. Consequently, the first enzymatic takeover of an ancient biochemistry or prebiotic chemistry was related to the synthesis of nucleotides for the RNA world.}, author = {Caetano-Anoll\~{A}{\copyright}s, Gustavo and Kim, Hee S. and Mittenthal, Jay E.}, citeulike-article-id = {1457751}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0701214104}, citeulike-linkout-1 = {http://www.pnas.org/content/104/22/9358.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/104/22/9358.full.pdf}, citeulike-linkout-3 = {http://www.pnas.org/cgi/content/abstract/104/22/9358}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/17517598}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=17517598}, day = {29}, doi = {10.1073/pnas.0701214104}, journal = {Proceedings of the National Academy of Sciences}, keywords = {evolution}, month = {May}, number = {22}, pages = {9358--9363}, posted-at = {2007-10-02 00:25:42}, priority = {0}, title = {The origin of modern metabolic networks inferred from phylogenomic analysis of protein architecture}, url = {http://dx.doi.org/10.1073/pnas.0701214104}, volume = {104}, year = {2007} }

TY - JOUR ID - citeulike:1457751 L3 - citeulike-article-id:1457751 N2 - 10.1073/pnas.0701214104 Metabolism represents a complex collection of enzymatic reactions and transport processes that convert metabolites into molecules capable of supporting cellular life. Here we explore the origins and evolution of modern metabolism. Using phylogenomic information linked to the structure of metabolic enzymes, we sort out recruitment processes and discover that most enzymatic activities were associated with the nine most ancient and widely distributed protein fold architectures. An analysis of newly discovered functions showed enzymatic diversification occurred early, during the onset of the modern protein world. Most importantly, phylogenetic reconstruction exercises and other evidence suggest strongly that metabolism originated in enzymes with the P-loop hydrolase fold in nucleotide metabolism, probably in pathways linked to the purine metabolic subnetwork. Consequently, the first enzymatic takeover of an ancient biochemistry or prebiotic chemistry was related to the synthesis of nucleotides for the RNA world. IS - 22 JF - Proceedings of the National Academy of Sciences EP - 9363 TI - The origin of modern metabolic networks inferred from phylogenomic analysis of protein architecture VL - 104 SP - 9358 KW - evolution AU - Caetano-Anollés, Gustavo AU - Kim, Hee AU - Mittenthal, Jay PY - 2007/05/29/ UR - http://dx.doi.org/10.1073/pnas.0701214104 ER -