The use of mass spectrometry for the proteomic analysis of glycosylation Export

@article{citeulike:4095627, abstract = {Of all protein PTMs, glycosylation is by far the most common, and is a target for proteomic research. Glycosylation plays key roles in controlling various cellular processes and the modifications of the glycan structures in diseases highlight the clinical importance of this PTM. Glycosylation analysis remains a difficult task. MS, in combination with modern separation methodologies, is one of the most powerful and versatile techniques for the structural analysis of glycoconjugates. This review describes methodologies based on MS for detailed characterization of glycoconjugates in complex biological samples at the sensitivity required for proteomic work.}, address = {Unit\'{e} Mixte de Recherche CNRS/USTL 8576, Universit\'{e} des Sciences et Technologies de Lille 1, Villeneuve d'Ascq Cedex, France}, author = {Morelle, Willy and Canis, K\'{e}vin and Chirat, Fr\'{e}d\'{e}ric and Faid, Valegh and Michalski, Jean-Claude}, citeulike-article-id = {4095627}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/pmic.200600129}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/112657176/ABSTRACT}, doi = {10.1002/pmic.200600129}, journal = {PROTEOMICS}, keywords = {glycoproteomics}, number = {14}, pages = {3993--4015}, posted-at = {2009-02-24 23:56:18}, priority = {2}, title = {The use of mass spectrometry for the proteomic analysis of glycosylation}, url = {http://dx.doi.org/10.1002/pmic.200600129}, volume = {6}, year = {2006} }

TY - JOUR ID - citeulike:4095627 L3 - citeulike-article-id:4095627 N2 - Of all protein PTMs, glycosylation is by far the most common, and is a target for proteomic research. Glycosylation plays key roles in controlling various cellular processes and the modifications of the glycan structures in diseases highlight the clinical importance of this PTM. Glycosylation analysis remains a difficult task. MS, in combination with modern separation methodologies, is one of the most powerful and versatile techniques for the structural analysis of glycoconjugates. This review describes methodologies based on MS for detailed characterization of glycoconjugates in complex biological samples at the sensitivity required for proteomic work. IS - 14 JF - PROTEOMICS AD - Unité Mixte de Recherche CNRS/USTL 8576, Université des Sciences et Technologies de Lille 1, Villeneuve d'Ascq Cedex, France EP - 4015 TI - The use of mass spectrometry for the proteomic analysis of glycosylation VL - 6 SP - 3993 KW - glycoproteomics AU - Morelle, Willy AU - Canis, Kévin AU - Chirat, Frédéric AU - Faid, Valegh AU - Michalski, Jean-Claude PY - 2006/// UR - http://dx.doi.org/10.1002/pmic.200600129 ER -