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Polymers in drug delivery

by: Omathanu Pillai, Ramesh Panchagnula
Current Opinion in Chemical Biology, Vol. 5, No. 4. (August 2001), pp. 447-451, doi:10.1016/s1367-5931(00)00227-1  Key: citeulike:11894125

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Abstract

Advances in polymer science have led to the development of several novel drug-delivery sytems. A proper consideration of surface and bulk properties can aid in the designing of polymers for various drug-delivery applications. Biodegradable polymers find widespread use in drug delivery as they can be degraded to non-toxic monomers inside the body. Novel supramolecular structures based on polyethylene oxide copolymers and dendrimers are being intensively researched for delivery of genes and macromolecules. Hydrogels that can respond to a variety of physical, chemical and biological stimuli hold enormous potential for design of closed-loop drug-delivery systems. Design and synthesis of novel combinations of polymers will expand the scope of new drug-delivery systems in the future.


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