Computer-aided design of functional protein interactions Export

@article{citeulike:6044004, abstract = {Predictive methods for the computational design of proteins search for amino acid sequences adopting desired structures that perform specific functions. Typically, design of 'function' is formulated as engineering new and altered binding activities into proteins. Progress in the design of functional protein-protein interactions is directed toward engineering proteins to precisely control biological processes by specifically recognizing desired interaction partners while avoiding competitors. The field is aiming for strategies to harness recent advances in high-resolution computational modeling—particularly those exploiting protein conformational variability—to engineer new functions and incorporate many functional requirements simultaneously.}, author = {Mandell, Daniel J. and Kortemme, Tanja}, booktitle = {Nat Chem Biol}, citeulike-article-id = {6044004}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nchembio.251}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nchembio.251}, day = {19}, doi = {10.1038/nchembio.251}, issn = {1552-4450}, journal = {Nature Chemical Biology}, keywords = {drug-design, protein-protein}, month = {October}, number = {11}, pages = {797--807}, posted-at = {2009-11-03 20:48:21}, priority = {2}, publisher = {Nature Publishing Group}, title = {Computer-aided design of functional protein interactions}, url = {http://dx.doi.org/10.1038/nchembio.251}, volume = {5}, year = {2009} }

TY - JOUR ID - citeulike:6044004 L3 - citeulike-article-id:6044004 N2 - Predictive methods for the computational design of proteins search for amino acid sequences adopting desired structures that perform specific functions. Typically, design of 'function' is formulated as engineering new and altered binding activities into proteins. Progress in the design of functional protein-protein interactions is directed toward engineering proteins to precisely control biological processes by specifically recognizing desired interaction partners while avoiding competitors. The field is aiming for strategies to harness recent advances in high-resolution computational modeling—particularly those exploiting protein conformational variability—to engineer new functions and incorporate many functional requirements simultaneously. IS - 11 JF - Nature Chemical Biology SN - 1552-4450 EP - 807 TI - Computer-aided design of functional protein interactions PB - Nature Publishing Group VL - 5 T2 - Nat Chem Biol SP - 797 KW - drug-design KW - protein-protein AU - Mandell, Daniel AU - Kortemme, Tanja PY - 2009/10/19/ UR - http://dx.doi.org/10.1038/nchembio.251 ER -