Synaptic mechanisms for plasticity in neocortex. Export

@article{citeulike:5406444, abstract = {Sensory experience and learning alter sensory representations in cerebral cortex. The synaptic mechanisms underlying sensory cortical plasticity have long been sought. Recent work indicates that long-term cortical plasticity is a complex, multicomponent process involving multiple synaptic and cellular mechanisms. Sensory use, disuse, and training drive long-term potentiation and depression (LTP and LTD), homeostatic synaptic plasticity and plasticity of intrinsic excitability, and structural changes including formation, removal, and morphological remodeling of cortical synapses and dendritic spines. Both excitatory and inhibitory circuits are strongly regulated by experience. This review summarizes these findings and proposes that these mechanisms map onto specific functional components of plasticity, which occur in common across the primary somatosensory, visual, and auditory cortices.}, author = {Feldman, Daniel E.}, citeulike-article-id = {5406444}, citeulike-linkout-0 = {http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.neuro.051508.135516}, citeulike-linkout-1 = {http://dx.doi.org/10.1146/annurev.neuro.051508.135516}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19400721}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19400721}, doi = {10.1146/annurev.neuro.051508.135516}, issn = {1545-4126}, journal = {Annual review of neuroscience}, keywords = {cortex, ltd, ltp, plasticity, representation, synaptic\_plasticity, v1}, number = {1}, pages = {33--55}, posted-at = {2009-08-10 23:09:59}, priority = {2}, title = {Synaptic mechanisms for plasticity in neocortex.}, url = {http://dx.doi.org/10.1146/annurev.neuro.051508.135516}, volume = {32}, year = {2009} }

TY - JOUR ID - citeulike:5406444 L3 - citeulike-article-id:5406444 N2 - Sensory experience and learning alter sensory representations in cerebral cortex. The synaptic mechanisms underlying sensory cortical plasticity have long been sought. Recent work indicates that long-term cortical plasticity is a complex, multicomponent process involving multiple synaptic and cellular mechanisms. Sensory use, disuse, and training drive long-term potentiation and depression (LTP and LTD), homeostatic synaptic plasticity and plasticity of intrinsic excitability, and structural changes including formation, removal, and morphological remodeling of cortical synapses and dendritic spines. Both excitatory and inhibitory circuits are strongly regulated by experience. This review summarizes these findings and proposes that these mechanisms map onto specific functional components of plasticity, which occur in common across the primary somatosensory, visual, and auditory cortices. IS - 1 JF - Annual review of neuroscience SN - 1545-4126 EP - 55 TI - Synaptic mechanisms for plasticity in neocortex. VL - 32 SP - 33 KW - cortex KW - ltd KW - ltp KW - plasticity KW - representation KW - synaptic_plasticity KW - v1 AU - Feldman, Daniel PY - 2009/// UR - http://dx.doi.org/10.1146/annurev.neuro.051508.135516 ER -