Rapid Loss of Dendritic Spines after Stress Involves Derangement of Spine Dynamics by Corticotropin-Releasing Hormone Export

@article{citeulike:2522056, abstract = {Chronic stress causes dendritic regression and loss of dendritic spines in hippocampal neurons that is accompanied by deficits in synaptic plasticity and memory. However, the responsible mechanisms remain unresolved. Here, we found that within hours of the onset of stress, the density of dendritic spines declined in vulnerable dendritic domains. This rapid, stress-induced spine loss was abolished by blocking the receptor (CRFR1) of corticotropin-releasing hormone (CRH), a hippocampal neuropeptide released during stress. Exposure to CRH provoked spine loss and dendritic regression in hippocampal organotypic cultures, and selective blockade of the CRFR1 receptor had the opposite effect. Live, time-lapse imaging revealed that CRH reduced spine density by altering dendritic spine dynamics: the peptide selectively and reversibly accelerated spine retraction, and this mechanism involved destabilization of spine F-actin. In addition, mice lacking the CRFR1 receptor had augmented spine density. These findings support a mechanistic role for CRHCRFR1 signaling in stress-evoked spine loss and dendritic remodeling. 10.1523/JNEUROSCI.0225-08.2008}, author = {Chen, Yuncai and Dube, Celine M. and Rice, Courtney J. and Baram, Tallie Z.}, citeulike-article-id = {2522056}, citeulike-linkout-0 = {http://dx.doi.org/10.1523/JNEUROSCI.0225-08.2008}, citeulike-linkout-1 = {http://www.jneurosci.org/cgi/content/abstract/28/11/2903}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18337421}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18337421}, day = {12}, doi = {10.1523/JNEUROSCI.0225-08.2008}, journal = {J. Neurosci.}, keywords = {2p, corticoids, hormone, mouse, remodeling, spine, stress, structure}, month = {March}, number = {11}, pages = {2903--2911}, posted-at = {2008-06-19 12:48:16}, priority = {1}, title = {Rapid Loss of Dendritic Spines after Stress Involves Derangement of Spine Dynamics by Corticotropin-Releasing Hormone}, url = {http://dx.doi.org/10.1523/JNEUROSCI.0225-08.2008}, volume = {28}, year = {2008} }

TY - JOUR ID - citeulike:2522056 L3 - citeulike-article-id:2522056 N2 - Chronic stress causes dendritic regression and loss of dendritic spines in hippocampal neurons that is accompanied by deficits in synaptic plasticity and memory. However, the responsible mechanisms remain unresolved. Here, we found that within hours of the onset of stress, the density of dendritic spines declined in vulnerable dendritic domains. This rapid, stress-induced spine loss was abolished by blocking the receptor (CRFR1) of corticotropin-releasing hormone (CRH), a hippocampal neuropeptide released during stress. Exposure to CRH provoked spine loss and dendritic regression in hippocampal organotypic cultures, and selective blockade of the CRFR1 receptor had the opposite effect. Live, time-lapse imaging revealed that CRH reduced spine density by altering dendritic spine dynamics: the peptide selectively and reversibly accelerated spine retraction, and this mechanism involved destabilization of spine F-actin. In addition, mice lacking the CRFR1 receptor had augmented spine density. These findings support a mechanistic role for CRHCRFR1 signaling in stress-evoked spine loss and dendritic remodeling. 10.1523/JNEUROSCI.0225-08.2008 IS - 11 JF - J. Neurosci. EP - 2911 TI - Rapid Loss of Dendritic Spines after Stress Involves Derangement of Spine Dynamics by Corticotropin-Releasing Hormone VL - 28 SP - 2903 KW - 2p KW - corticoids KW - hormone KW - mouse KW - remodeling KW - spine KW - stress KW - structure AU - Chen, Yuncai AU - Dube, Celine AU - Rice, Courtney AU - Baram, Tallie PY - 2008/03/12/ UR - http://dx.doi.org/10.1523/JNEUROSCI.0225-08.2008 ER -