Transient Spine Expansion and Learning-Induced Plasticity in Layer 1 Primary Motor Cortex Export

@article{citeulike:2931026, abstract = {Experience-dependent regulation of synaptic strength in the horizontal connections in layer 1 of the primary motor cortex is likely to play an important role in motor learning. Dendritic spines, the primary sites of excitatory synapses in the brain, are known to change shape in response to various experimental stimuli. We used a rat motor learning model to examine connection strength via field recordings in slices and confocal imaging of labeled spines to explore changes induced solely by learning a simple motor task. We report that motor learning increases response size, while transiently occluding long-term potentiation (LTP) and increasing spine width in layer 1. This demonstrates learning-induced changes in behavior, synaptic responses, and structure in the same animal, suggesting that an LTP-like process in the motor cortex mediates the initial learning of a skilled task. 10.1523/JNEUROSCI.0584-08.2008}, author = {Harms, Kimberly J. and Rioult-Pedotti, Mengia S. and Carter, Rosy D. and Dunaevsky, Anna}, citeulike-article-id = {2931026}, citeulike-linkout-0 = {http://dx.doi.org/10.1523/JNEUROSCI.0584-08.2008}, citeulike-linkout-1 = {http://www.jneurosci.org/cgi/content/abstract/28/22/5686}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18509029}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18509029}, day = {28}, doi = {10.1523/JNEUROSCI.0584-08.2008}, journal = {J. Neurosci.}, keywords = {experience-dependent, l-and-m, m1, motor-learning, plasticity, rat, spine}, month = {May}, number = {22}, pages = {5686--5690}, posted-at = {2008-06-26 13:27:09}, priority = {4}, title = {Transient Spine Expansion and Learning-Induced Plasticity in Layer 1 Primary Motor Cortex}, url = {http://dx.doi.org/10.1523/JNEUROSCI.0584-08.2008}, volume = {28}, year = {2008} }

TY - JOUR ID - citeulike:2931026 L3 - citeulike-article-id:2931026 N2 - Experience-dependent regulation of synaptic strength in the horizontal connections in layer 1 of the primary motor cortex is likely to play an important role in motor learning. Dendritic spines, the primary sites of excitatory synapses in the brain, are known to change shape in response to various experimental stimuli. We used a rat motor learning model to examine connection strength via field recordings in slices and confocal imaging of labeled spines to explore changes induced solely by learning a simple motor task. We report that motor learning increases response size, while transiently occluding long-term potentiation (LTP) and increasing spine width in layer 1. This demonstrates learning-induced changes in behavior, synaptic responses, and structure in the same animal, suggesting that an LTP-like process in the motor cortex mediates the initial learning of a skilled task. 10.1523/JNEUROSCI.0584-08.2008 IS - 22 JF - J. Neurosci. EP - 5690 TI - Transient Spine Expansion and Learning-Induced Plasticity in Layer 1 Primary Motor Cortex VL - 28 SP - 5686 KW - experience-dependent KW - l-and-m KW - m1 KW - motor-learning KW - plasticity KW - rat KW - spine AU - Harms, Kimberly AU - Rioult-Pedotti, Mengia AU - Carter, Rosy AU - Dunaevsky, Anna PY - 2008/05/28/ UR - http://dx.doi.org/10.1523/JNEUROSCI.0584-08.2008 ER -