The Evolutionary Genetics and Emergence of Avian Influenza Viruses in Wild Birds Export

@article{citeulike:4280854, abstract = {We surveyed the genetic diversity among avian influenza virus (AIV) in wild birds, comprising 167 complete viral genomes from 14 bird species sampled in four locations across the United States. These isolates represented 29 type A influenza virus hemagglutinin (HA) and neuraminidase (NA) subtype combinations, with up to 26\% of isolates showing evidence of mixed subtype infection. Through a phylogenetic analysis of the largest data set of AIV genomes compiled to date, we were able to document a remarkably high rate of genome reassortment, with no clear pattern of gene segment association and occasional inter-hemisphere gene segment migration and reassortment. From this, we propose that AIV in wild birds forms transient \^{a}€{\oe}genome constellations,\^{a}€� continually reshuffled by reassortment, in contrast to the spread of a limited number of stable genome constellations that characterizes the evolution of mammalian-adapted influenza A viruses.}, author = {Dugan, Vivien G. and Chen, Rubing and Spiro, David J. and Sengamalay, Naomi and Zaborsky, Jennifer and Ghedin, Elodie and Nolting, Jacqueline and Swayne, David E. and Runstadler, Jonathan A. and Happ, George M. and Senne, Dennis A. and Wang, Ruixue and Slemons, Richard D. and Holmes, Edward C. and Taubenberger, Jeffery K.}, citeulike-article-id = {4280854}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.ppat.1000076}, day = {30}, doi = {10.1371/journal.ppat.1000076}, journal = {PLoS Pathog}, keywords = {avian, bird, influenza, wild}, month = {May}, number = {5}, pages = {e1000076+}, posted-at = {2009-04-07 04:31:56}, priority = {2}, publisher = {Public Library of Science}, title = {The Evolutionary Genetics and Emergence of Avian Influenza Viruses in Wild Birds}, url = {http://dx.doi.org/10.1371/journal.ppat.1000076}, volume = {4}, year = {2008} }

TY - JOUR ID - citeulike:4280854 L3 - citeulike-article-id:4280854 N2 - We surveyed the genetic diversity among avian influenza virus (AIV) in wild birds, comprising 167 complete viral genomes from 14 bird species sampled in four locations across the United States. These isolates represented 29 type A influenza virus hemagglutinin (HA) and neuraminidase (NA) subtype combinations, with up to 26% of isolates showing evidence of mixed subtype infection. Through a phylogenetic analysis of the largest data set of AIV genomes compiled to date, we were able to document a remarkably high rate of genome reassortment, with no clear pattern of gene segment association and occasional inter-hemisphere gene segment migration and reassortment. From this, we propose that AIV in wild birds forms transient “genome constellations,� continually reshuffled by reassortment, in contrast to the spread of a limited number of stable genome constellations that characterizes the evolution of mammalian-adapted influenza A viruses. IS - 5 JF - PLoS Pathog TI - The Evolutionary Genetics and Emergence of Avian Influenza Viruses in Wild Birds PB - Public Library of Science VL - 4 SP - e1000076 KW - avian KW - bird KW - influenza KW - wild AU - Dugan, Vivien AU - Chen, Rubing AU - Spiro, David AU - Sengamalay, Naomi AU - Zaborsky, Jennifer AU - Ghedin, Elodie AU - Nolting, Jacqueline AU - Swayne, David AU - Runstadler, Jonathan AU - Happ, George AU - Senne, Dennis AU - Wang, Ruixue AU - Slemons, Richard AU - Holmes, Edward AU - Taubenberger, Jeffery PY - 2008/05/30/ UR - http://dx.doi.org/10.1371/journal.ppat.1000076 ER -