Comparison of the Mutation Rates of Human Influenza A and B Viruses Export

@article{citeulike:4293869, abstract = {Human influenza A viruses evolve more rapidly than influenza B viruses. To clarify the cause of this difference, we have evaluated the mutation rate of the nonstructural gene as revealed by the genetic diversity observed during the growth of individual plaques in MDCK cells. Six plaques were studied, representing two strains each of type A and B viruses. A total of 813,663 nucleotides were sequenced, giving rates of 2.0 x 10-6 and 0.6 x 10-6 mutations per site per infectious cycle, which, when extended to 1 year, agree well with the published annual evolutionary rates. 10.1128/JVI.80.7.3675-3678.2006}, author = {Nobusawa, Eri and Sato, Katsuhiko}, citeulike-article-id = {4293869}, citeulike-linkout-0 = {http://dx.doi.org/10.1128/JVI.80.7.3675-3678.2006}, citeulike-linkout-1 = {http://jvi.asm.org/cgi/content/abstract/80/7/3675}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16537638}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16537638}, day = {1}, doi = {10.1128/JVI.80.7.3675-3678.2006}, journal = {J. Virol.}, keywords = {a, b, influenza, mutation, ns, rate}, month = {April}, number = {7}, pages = {3675--3678}, posted-at = {2009-04-09 10:05:56}, priority = {2}, title = {Comparison of the Mutation Rates of Human Influenza A and B Viruses}, url = {http://dx.doi.org/10.1128/JVI.80.7.3675-3678.2006}, volume = {80}, year = {2006} }

TY - JOUR ID - citeulike:4293869 L3 - citeulike-article-id:4293869 N2 - Human influenza A viruses evolve more rapidly than influenza B viruses. To clarify the cause of this difference, we have evaluated the mutation rate of the nonstructural gene as revealed by the genetic diversity observed during the growth of individual plaques in MDCK cells. Six plaques were studied, representing two strains each of type A and B viruses. A total of 813,663 nucleotides were sequenced, giving rates of 2.0 x 10-6 and 0.6 x 10-6 mutations per site per infectious cycle, which, when extended to 1 year, agree well with the published annual evolutionary rates. 10.1128/JVI.80.7.3675-3678.2006 IS - 7 JF - J. Virol. EP - 3678 TI - Comparison of the Mutation Rates of Human Influenza A and B Viruses VL - 80 SP - 3675 KW - a KW - b KW - influenza KW - mutation KW - ns KW - rate AU - Nobusawa, Eri AU - Sato, Katsuhiko PY - 2006/04/01/ UR - http://dx.doi.org/10.1128/JVI.80.7.3675-3678.2006 ER -