Trapping Moving Targets with Small Molecules Export

@article{citeulike:4295674, abstract = {Structure-based drug design traditionally uses static protein models as inspirations for focusing on "active" site targets. Allosteric regulation of biological macromolecules, however, is affected by both conformational and dynamic properties of the protein or protein complex and can potentially lead to more avenues for therapeutic development. We discuss the advantages of searching for molecules that conformationally trap a macromolecule in its inactive state. Although multiple methodologies exist to probe protein dynamics and ligand binding, our current discussion highlights the use of nuclear magnetic resonance spectroscopy in the drug discovery and design process. 10.1126/science.1169378}, author = {Lee, Gregory M. and Craik, Charles S.}, citeulike-article-id = {4295674}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1169378}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/324/5924/213}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19359579}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19359579}, day = {10}, doi = {10.1126/science.1169378}, journal = {Science}, keywords = {design, drug, structure}, month = {April}, number = {5924}, pages = {213--215}, posted-at = {2009-04-10 02:17:17}, priority = {2}, title = {Trapping Moving Targets with Small Molecules}, url = {http://dx.doi.org/10.1126/science.1169378}, volume = {324}, year = {2009} }

TY - JOUR ID - citeulike:4295674 L3 - citeulike-article-id:4295674 N2 - Structure-based drug design traditionally uses static protein models as inspirations for focusing on "active" site targets. Allosteric regulation of biological macromolecules, however, is affected by both conformational and dynamic properties of the protein or protein complex and can potentially lead to more avenues for therapeutic development. We discuss the advantages of searching for molecules that conformationally trap a macromolecule in its inactive state. Although multiple methodologies exist to probe protein dynamics and ligand binding, our current discussion highlights the use of nuclear magnetic resonance spectroscopy in the drug discovery and design process. 10.1126/science.1169378 IS - 5924 JF - Science EP - 215 TI - Trapping Moving Targets with Small Molecules VL - 324 SP - 213 KW - design KW - drug KW - structure AU - Lee, Gregory AU - Craik, Charles PY - 2009/04/10/ UR - http://dx.doi.org/10.1126/science.1169378 ER -