Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer. Export

@article{citeulike:3730148, abstract = {Microarray analysis has been shown to improve risk stratification of breast cancer. Breast tumors analyzed by hierarchical clustering of expression patterns of "intrinsic" genes have been reported to subdivide into at least four molecular subtypes that are associated with distinct patient outcomes. Using a supervised method, a 70-gene expression profile has been identified that predicts the later appearance or absence of clinical metastasis in young breast cancer patients. Here, we show that distant metastases display both the same molecular breast cancer subtype as well as the 70-gene prognosis signature as their primary tumors. Our results suggest that the capacity to metastasize is an inherent feature of most breast cancers. Furthermore, our data imply that poor prognosis breast carcinomas classified either by the intrinsic gene set or the 70 prognosis genes represent distinct disease entities that seem sustained throughout the metastatic process.}, author = {Weigelt, B. and Hu, Z. and He, X. and Livasy, C. and Carey, L. A. and Ewend, M. G. and Glas, A. M. and Perou, C. M. and Van't Veer, L. J.}, citeulike-article-id = {3730148}, citeulike-linkout-0 = {http://dx.doi.org/10.1158/0008-5472.CAN-05-2553}, citeulike-linkout-1 = {http://cancerres.aacrjournals.org/cgi/content/abstract/65/20/9155}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16230372}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16230372}, day = {15}, doi = {10.1158/0008-5472.CAN-05-2553}, issn = {0008-5472}, journal = {Cancer research}, keywords = {70-gene, breast-cancer, metastases, metastases-signature}, month = {October}, number = {20}, pages = {9155--9158}, posted-at = {2009-05-05 17:07:25}, priority = {2}, title = {Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer.}, url = {http://dx.doi.org/10.1158/0008-5472.CAN-05-2553}, volume = {65}, year = {2005} }

TY - JOUR ID - citeulike:3730148 L3 - citeulike-article-id:3730148 N2 - Microarray analysis has been shown to improve risk stratification of breast cancer. Breast tumors analyzed by hierarchical clustering of expression patterns of "intrinsic" genes have been reported to subdivide into at least four molecular subtypes that are associated with distinct patient outcomes. Using a supervised method, a 70-gene expression profile has been identified that predicts the later appearance or absence of clinical metastasis in young breast cancer patients. Here, we show that distant metastases display both the same molecular breast cancer subtype as well as the 70-gene prognosis signature as their primary tumors. Our results suggest that the capacity to metastasize is an inherent feature of most breast cancers. Furthermore, our data imply that poor prognosis breast carcinomas classified either by the intrinsic gene set or the 70 prognosis genes represent distinct disease entities that seem sustained throughout the metastatic process. IS - 20 JF - Cancer research SN - 0008-5472 EP - 9158 TI - Molecular portraits and 70-gene prognosis signature are preserved throughout the metastatic process of breast cancer. VL - 65 SP - 9155 KW - 70-gene KW - breast-cancer KW - metastases KW - metastases-signature AU - Weigelt, B AU - Hu, Z AU - He, X AU - Livasy, C AU - Carey, LA AU - Ewend, MG AU - Glas, AM AU - Perou, CM AU - Van't Veer, LJ PY - 2005/10/15/ UR - http://dx.doi.org/10.1158/0008-5472.CAN-05-2553 ER -