MicroRNA gene expression deregulation in human breast cancer. Export

@article{citeulike:455558, abstract = {MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression by targeting mRNAs and triggering either translation repression or RNA degradation. Their aberrant expression may be involved in human diseases, including cancer. Indeed, miRNA aberrant expression has been previously found in human chronic lymphocytic leukemias, where miRNA signatures were associated with specific clinicobiological features. Here, we show that, compared with normal breast tissue, miRNAs are also aberrantly expressed in human breast cancer. The overall miRNA expression could clearly separate normal versus cancer tissues, with the most significantly deregulated miRNAs being mir-125b, mir-145, mir-21, and mir-155. Results were confirmed by microarray and Northern blot analyses. We could identify miRNAs whose expression was correlated with specific breast cancer biopathologic features, such as estrogen and progesterone receptor expression, tumor stage, vascular invasion, or proliferation index.}, address = {Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA.}, author = {Iorio, Marilena V. and Ferracin, Manuela and Liu, Chang-Gong G. and Veronese, Angelo and Spizzo, Riccardo and Sabbioni, Silvia and Magri, Eros and Pedriali, Massimo and Fabbri, Muller and Campiglio, Manuela and M\'{e}nard, Sylvie and Palazzo, Juan P. and Rosenberg, Anne and Musiani, Piero and Volinia, Stefano and Nenci, Italo and Calin, George A. and Querzoli, Patrizia and Negrini, Massimo and Croce, Carlo M.}, citeulike-article-id = {455558}, citeulike-linkout-0 = {http://dx.doi.org/10.1158/0008-5472.CAN-05-1783}, citeulike-linkout-1 = {http://cancerres.aacrjournals.org/content/65/16/7065.abstract}, citeulike-linkout-2 = {http://cancerres.aacrjournals.org/content/65/16/7065.full.pdf}, citeulike-linkout-3 = {http://cancerres.aacrjournals.org/cgi/content/abstract/65/16/7065}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/16103053}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=16103053}, day = {15}, doi = {10.1158/0008-5472.CAN-05-1783}, issn = {0008-5472}, journal = {Cancer research}, keywords = {breast-cancer, microrna}, month = {August}, number = {16}, pages = {7065--7070}, posted-at = {2008-09-15 13:02:09}, priority = {2}, title = {MicroRNA gene expression deregulation in human breast cancer.}, url = {http://dx.doi.org/10.1158/0008-5472.CAN-05-1783}, volume = {65}, year = {2005} }

TY - JOUR ID - citeulike:455558 L3 - citeulike-article-id:455558 N2 - MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression by targeting mRNAs and triggering either translation repression or RNA degradation. Their aberrant expression may be involved in human diseases, including cancer. Indeed, miRNA aberrant expression has been previously found in human chronic lymphocytic leukemias, where miRNA signatures were associated with specific clinicobiological features. Here, we show that, compared with normal breast tissue, miRNAs are also aberrantly expressed in human breast cancer. The overall miRNA expression could clearly separate normal versus cancer tissues, with the most significantly deregulated miRNAs being mir-125b, mir-145, mir-21, and mir-155. Results were confirmed by microarray and Northern blot analyses. We could identify miRNAs whose expression was correlated with specific breast cancer biopathologic features, such as estrogen and progesterone receptor expression, tumor stage, vascular invasion, or proliferation index. IS - 16 JF - Cancer research SN - 0008-5472 AD - Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA. EP - 7070 TI - MicroRNA gene expression deregulation in human breast cancer. VL - 65 SP - 7065 KW - breast-cancer KW - microrna AU - Iorio, Marilena AU - Ferracin, Manuela AU - Liu, Chang-Gong AU - Veronese, Angelo AU - Spizzo, Riccardo AU - Sabbioni, Silvia AU - Magri, Eros AU - Pedriali, Massimo AU - Fabbri, Muller AU - Campiglio, Manuela AU - Ménard, Sylvie AU - Palazzo, Juan AU - Rosenberg, Anne AU - Musiani, Piero AU - Volinia, Stefano AU - Nenci, Italo AU - Calin, George AU - Querzoli, Patrizia AU - Negrini, Massimo AU - Croce, Carlo PY - 2005/08/15/ UR - http://dx.doi.org/10.1158/0008-5472.CAN-05-1783 ER -