Metabolomics Reveals Metabolic Biomarkers of Crohn's Disease Export

@article{citeulike:5288036, abstract = {The causes and etiology of Crohn's disease (CD) are currently unknown although both host genetics and environmental factors play a role. Here we used non-targeted metabolic profiling to determine the contribution of metabolites produced by the gut microbiota towards disease status of the host. Ion Cyclotron Resonance Fourier Transform Mass Spectrometry (ICR-FT/MS) was used to discern the masses of thousands of metabolites in fecal samples collected from 17 identical twin pairs, including healthy individuals and those with CD. Pathways with differentiating metabolites included those involved in the metabolism and or synthesis of amino acids, fatty acids, bile acids and arachidonic acid. Several metabolites were positively or negatively correlated to the disease phenotype and to specific microbes previously characterized in the same samples. Our data reveal novel differentiating metabolites for CD that may provide diagnostic biomarkers and/or monitoring tools as well as insight into potential targets for disease therapy and prevention.}, author = {Jansson, Janet and Willing, Ben and Lucio, Marianna and Fekete, Ages and Dicksved, Johan and Halfvarson, Jonas and Tysk, Curt and Schmitt-Kopplin, Philippe}, citeulike-article-id = {5288036}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pone.0006386}, day = {28}, doi = {10.1371/journal.pone.0006386}, journal = {PLoS ONE}, keywords = {biomarker, crohn, mass-spectrometry, metabolomics}, month = {July}, number = {7}, pages = {e6386+}, posted-at = {2009-08-14 09:06:23}, priority = {2}, publisher = {Public Library of Science}, title = {Metabolomics Reveals Metabolic Biomarkers of Crohn's Disease}, url = {http://dx.doi.org/10.1371/journal.pone.0006386}, volume = {4}, year = {2009} }

TY - JOUR ID - citeulike:5288036 L3 - citeulike-article-id:5288036 N2 - The causes and etiology of Crohn's disease (CD) are currently unknown although both host genetics and environmental factors play a role. Here we used non-targeted metabolic profiling to determine the contribution of metabolites produced by the gut microbiota towards disease status of the host. Ion Cyclotron Resonance Fourier Transform Mass Spectrometry (ICR-FT/MS) was used to discern the masses of thousands of metabolites in fecal samples collected from 17 identical twin pairs, including healthy individuals and those with CD. Pathways with differentiating metabolites included those involved in the metabolism and or synthesis of amino acids, fatty acids, bile acids and arachidonic acid. Several metabolites were positively or negatively correlated to the disease phenotype and to specific microbes previously characterized in the same samples. Our data reveal novel differentiating metabolites for CD that may provide diagnostic biomarkers and/or monitoring tools as well as insight into potential targets for disease therapy and prevention. IS - 7 JF - PLoS ONE TI - Metabolomics Reveals Metabolic Biomarkers of Crohn's Disease PB - Public Library of Science VL - 4 SP - e6386 KW - biomarker KW - crohn KW - mass-spectrometry KW - metabolomics AU - Jansson, Janet AU - Willing, Ben AU - Lucio, Marianna AU - Fekete, Ages AU - Dicksved, Johan AU - Halfvarson, Jonas AU - Tysk, Curt AU - Schmitt-Kopplin, Philippe PY - 2009/07/28/ UR - http://dx.doi.org/10.1371/journal.pone.0006386 ER -