Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Export

@article{citeulike:553933, abstract = {MicroRNA (miRNA) expression profiles for lung cancers were examined to investigate miRNA's involvement in lung carcinogenesis. miRNA microarray analysis identified statistical unique profiles, which could discriminate lung cancers from noncancerous lung tissues as well as molecular signatures that differ in tumor histology. miRNA expression profiles correlated with survival of lung adenocarcinomas, including those classified as disease stage I. High hsa-mir-155 and low hsa-let-7a-2 expression correlated with poor survival by univariate analysis as well as multivariate analysis for hsa-mir-155. The miRNA expression signature on outcome was confirmed by real-time RT-PCR analysis of precursor miRNAs and cross-validated with an independent set of adenocarcinomas. These results indicate that miRNA expression profiles are diagnostic and prognostic markers of lung cancer.}, address = {Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.}, author = {Yanaihara, Nozomu and Caplen, Natasha and Bowman, Elise and Seike, Masahiro and Kumamoto, Kensuke and Yi, Ming and Stephens, Robert M. and Okamoto, Aikou and Yokota, Jun and Tanaka, Tadao and Calin, George Adrian A. and Liu, Chang-Gong G. and Croce, Carlo M. and Harris, Curtis C.}, citeulike-article-id = {553933}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.ccr.2006.01.025}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16530703}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16530703}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6WWK-4JG4MMJ-7/1/197e32c716e415526fdf9d5877ca2f06}, doi = {10.1016/j.ccr.2006.01.025}, issn = {1535-6108}, journal = {Cancer cell}, keywords = {lung-cancer, microrna}, month = {March}, number = {3}, pages = {189--198}, posted-at = {2008-09-15 13:04:52}, priority = {2}, title = {Unique microRNA molecular profiles in lung cancer diagnosis and prognosis.}, url = {http://dx.doi.org/10.1016/j.ccr.2006.01.025}, volume = {9}, year = {2006} }

TY - JOUR ID - citeulike:553933 L3 - citeulike-article-id:553933 N2 - MicroRNA (miRNA) expression profiles for lung cancers were examined to investigate miRNA's involvement in lung carcinogenesis. miRNA microarray analysis identified statistical unique profiles, which could discriminate lung cancers from noncancerous lung tissues as well as molecular signatures that differ in tumor histology. miRNA expression profiles correlated with survival of lung adenocarcinomas, including those classified as disease stage I. High hsa-mir-155 and low hsa-let-7a-2 expression correlated with poor survival by univariate analysis as well as multivariate analysis for hsa-mir-155. The miRNA expression signature on outcome was confirmed by real-time RT-PCR analysis of precursor miRNAs and cross-validated with an independent set of adenocarcinomas. These results indicate that miRNA expression profiles are diagnostic and prognostic markers of lung cancer. IS - 3 JF - Cancer cell SN - 1535-6108 AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892. EP - 198 TI - Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. VL - 9 SP - 189 KW - lung-cancer KW - microrna AU - Yanaihara, Nozomu AU - Caplen, Natasha AU - Bowman, Elise AU - Seike, Masahiro AU - Kumamoto, Kensuke AU - Yi, Ming AU - Stephens, Robert AU - Okamoto, Aikou AU - Yokota, Jun AU - Tanaka, Tadao AU - Calin, George Adrian AU - Liu, Chang-Gong AU - Croce, Carlo AU - Harris, Curtis PY - 2006/03// UR - http://dx.doi.org/10.1016/j.ccr.2006.01.025 ER -