Recurrent copy number alterations in BRCA1-mutated ovarian tumors alter biological pathways. Export

@article{citeulike:5915316, abstract = {Array CGH was used to identify recurrent copy number alterations (RCNA) characteristic of either BRCA1-related or sporadic ovarian cancer. After pre-processing, both groups of patients were modeled using a recurrent Hidden Markov Model to detect RCNA. RCNA with a probability higher than 80\% were called. After removing RCNA present in both groups, the genes present in the remaining RCNA were investigated for enrichment of pathways from external databases. More RCNA were observed in the BRCA1 group and they display more losses than gains compared to the sporadic group. When focusing on the type of RCNA, no significant difference in length was seen for the gains, but there was a statistically significant difference for the losses. In the sporadic group, a great proportion of the altered regions contain genes known to have a function in cell adhesion and complement activation whereas the BRCA1 samples are characterized by alterations in the HOX genes, metalloproteinases, tumor suppressor genes and the estrogen-signaling pathways. We conclude that BRCA1 ovarian tumors present a different type, number and length of RCNA; a huge amount of the genome is lost, resulting in important genomic instability. Moreover, important biological pathways are altered differentially when compared to the sporadic group. (c) 2009 Wiley-Liss, Inc.}, author = {Leunen, Karin and Gevaert, Olivier and Daemen, Anneleen and Vanspauwen, Vanessa and Michils, Genevi\`{e}ve and De Moor, Bart and Moerman, Philippe and Vergote, Ignace and Legius, Eric}, citeulike-article-id = {5915316}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/humu.21135}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19802895}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19802895}, day = {2}, doi = {10.1002/humu.21135}, issn = {1098-1004}, journal = {Human mutation}, keywords = {arraycgh, brca1, ovarian-cancer, pathway}, month = {October}, posted-at = {2009-10-13 08:07:49}, priority = {2}, title = {Recurrent copy number alterations in BRCA1-mutated ovarian tumors alter biological pathways.}, url = {http://dx.doi.org/10.1002/humu.21135}, year = {2009} }

TY - JOUR ID - citeulike:5915316 L3 - citeulike-article-id:5915316 N2 - Array CGH was used to identify recurrent copy number alterations (RCNA) characteristic of either BRCA1-related or sporadic ovarian cancer. After pre-processing, both groups of patients were modeled using a recurrent Hidden Markov Model to detect RCNA. RCNA with a probability higher than 80% were called. After removing RCNA present in both groups, the genes present in the remaining RCNA were investigated for enrichment of pathways from external databases. More RCNA were observed in the BRCA1 group and they display more losses than gains compared to the sporadic group. When focusing on the type of RCNA, no significant difference in length was seen for the gains, but there was a statistically significant difference for the losses. In the sporadic group, a great proportion of the altered regions contain genes known to have a function in cell adhesion and complement activation whereas the BRCA1 samples are characterized by alterations in the HOX genes, metalloproteinases, tumor suppressor genes and the estrogen-signaling pathways. We conclude that BRCA1 ovarian tumors present a different type, number and length of RCNA; a huge amount of the genome is lost, resulting in important genomic instability. Moreover, important biological pathways are altered differentially when compared to the sporadic group. (c) 2009 Wiley-Liss, Inc. JF - Human mutation SN - 1098-1004 TI - Recurrent copy number alterations in BRCA1-mutated ovarian tumors alter biological pathways. KW - arraycgh KW - brca1 KW - ovarian-cancer KW - pathway AU - Leunen, Karin AU - Gevaert, Olivier AU - Daemen, Anneleen AU - Vanspauwen, Vanessa AU - Michils, Geneviève AU - De Moor, Bart AU - Moerman, Philippe AU - Vergote, Ignace AU - Legius, Eric PY - 2009/10/02/ UR - http://dx.doi.org/10.1002/humu.21135 ER -