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Exercise and sport sciences reviews, Vol. 33, No. 4. (October 2005), pp. 189-194 Key: citeulike:12069940
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Leptin reduces intracellular lipid stores and improves insulin sensitivity. Thus, the development of leptin resistance in obesity may be an early event leading to elevated intramuscular lipids and insulin resistance. Recent data indicate that obesity-causing high-fat diets lead to leptin resistance in muscle, whereas supplementation with dietary fish oil and aerobic training can partially reverse this resistance.
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