Bacterial Protection of Beetle-Fungus Mutualism Export

@article{citeulike:3378159, abstract = {Host-microbe symbioses play a critical role in the evolution of biological diversity and complexity. In a notably intricate system, southern pine beetles use symbiotic fungi to help overcome host-tree defenses and to provide nutrition for their larvae. We show that this beetle-fungal mutualism is chemically mediated by a bacterially produced polyunsaturated peroxide. The molecule's selective toxicity toward the beetle's fungal antagonist, combined with the prevalence and localization of its bacterial source, indicates an insect-microbe association that is both mutualistic and coevolved. This unexpected finding in a well-studied system indicates that mutualistic associations between insects and antibiotic-producing bacteria are more common than currently recognized and that identifying their small-molecule mediators can provide a powerful search strategy for therapeutically useful antimicrobial compounds. 10.1126/science.1160423}, author = {Scott, Jarrod J. and Oh, Dong-Chan and Yuceer, Cetin M. and Klepzig, Kier D. and Clardy, Jon and Currie, Cameron R.}, citeulike-article-id = {3378159}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1160423}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/322/5898/63}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18832638}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18832638}, day = {3}, doi = {10.1126/science.1160423}, journal = {Science}, keywords = {actinomycetes, beetle, coleoptera, disease, fungi, pine, symbiosis, tree}, month = {October}, number = {5898}, pages = {63+}, posted-at = {2009-04-07 05:38:59}, priority = {2}, title = {Bacterial Protection of Beetle-Fungus Mutualism}, url = {http://dx.doi.org/10.1126/science.1160423}, volume = {322}, year = {2008} }

TY - JOUR ID - citeulike:3378159 L3 - citeulike-article-id:3378159 N2 - Host-microbe symbioses play a critical role in the evolution of biological diversity and complexity. In a notably intricate system, southern pine beetles use symbiotic fungi to help overcome host-tree defenses and to provide nutrition for their larvae. We show that this beetle-fungal mutualism is chemically mediated by a bacterially produced polyunsaturated peroxide. The molecule's selective toxicity toward the beetle's fungal antagonist, combined with the prevalence and localization of its bacterial source, indicates an insect-microbe association that is both mutualistic and coevolved. This unexpected finding in a well-studied system indicates that mutualistic associations between insects and antibiotic-producing bacteria are more common than currently recognized and that identifying their small-molecule mediators can provide a powerful search strategy for therapeutically useful antimicrobial compounds. 10.1126/science.1160423 IS - 5898 JF - Science TI - Bacterial Protection of Beetle-Fungus Mutualism VL - 322 SP - 63 KW - actinomycetes KW - beetle KW - coleoptera KW - disease KW - fungi KW - pine KW - symbiosis KW - tree AU - Scott, Jarrod AU - Oh, Dong-Chan AU - Yuceer, Cetin AU - Klepzig, Kier AU - Clardy, Jon AU - Currie, Cameron PY - 2008/10/03/ UR - http://dx.doi.org/10.1126/science.1160423 ER -