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GPCR activation of Ras and PI3K[gamma] in neutrophils depends on PLC[beta]2/[beta]3 and the RasGEF RasGRP4

by: Sabine Suire, Charlotte Lecureuil, Karen E. Anderson, George Damoulakis, Izabella Niewczas, Keith Davidson, Herve Guillou, Dingxin Pan, Jonathan Clark, Phillip T. Hawkins, Len Stephens
EMBO J, Vol. 31, No. 14. (18 July 2012), pp. 3118-3129, doi:10.1038/emboj.2012.167  Key: citeulike:10833501

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Abstract

GPCR activation of Ras and PI3K³ in neutrophils depends on PLC²2/²3 and the RasGEF RasGRP4RasGRP4, a RasGEF, is the missing link between GPCR-mediated activation of Ras and PI3K³ in pro-inflammatory signalling in mouse and human neutrophils.


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