Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells Export

@article{citeulike:2732430, abstract = {In hair follicles, dermal papilla (DP) and dermal sheath (DS) cells exhibit striking levels of plasticity, as each can regenerate both cell types. Here, we show that thrombin induces a phosphoinositide 3-kinase (PI3K)-Akt pathway-dependent acquisition of DS-like properties by DP cells in vitro, involving increased proliferation rate, acquisition of `myofibroblastic' contractile properties and a decreased capacity to sustain growth and survival of keratinocytes. The thrombin inhibitor protease nexin 1 [PN-1, also known as SERPINE2) regulates all those effects in vitro. Accordingly, the PI3K-Akt pathway is constitutively activated and expression of myofibroblastic marker smooth-muscle actin is enhanced in vivo in hair follicle dermal cells from PN-1-/- mice. Furthermore, physiological PN-1 disappearance and upregulation of the thrombin receptor PAR-1 (also known as F2R) during follicular regression in wild-type mice also correlate with such changes in DP cell characteristics. Our results indicate that control of thrombin signaling interferes with hair follicle dermal cells plasticity to regulate their function. 10.1242/jcs.018689}, author = {Feutz, Anne-Catherine and Barrandon, Yann and Monard, Denis}, citeulike-article-id = {2732430}, citeulike-linkout-0 = {http://dx.doi.org/10.1242/jcs.018689}, citeulike-linkout-1 = {http://jcs.biologists.org/cgi/content/abstract/121/9/1435}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18398001}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18398001}, day = {1}, doi = {10.1242/jcs.018689}, journal = {J Cell Sci}, keywords = {dermal\_sheath, hair\_follicle, papilla, pi3k}, month = {May}, number = {9}, pages = {1435--1443}, posted-at = {2008-04-29 09:21:08}, priority = {2}, title = {Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells}, url = {http://dx.doi.org/10.1242/jcs.018689}, volume = {121}, year = {2008} }

TY - JOUR ID - citeulike:2732430 L3 - citeulike-article-id:2732430 N2 - In hair follicles, dermal papilla (DP) and dermal sheath (DS) cells exhibit striking levels of plasticity, as each can regenerate both cell types. Here, we show that thrombin induces a phosphoinositide 3-kinase (PI3K)-Akt pathway-dependent acquisition of DS-like properties by DP cells in vitro, involving increased proliferation rate, acquisition of `myofibroblastic' contractile properties and a decreased capacity to sustain growth and survival of keratinocytes. The thrombin inhibitor protease nexin 1 [PN-1, also known as SERPINE2) regulates all those effects in vitro. Accordingly, the PI3K-Akt pathway is constitutively activated and expression of myofibroblastic marker smooth-muscle actin is enhanced in vivo in hair follicle dermal cells from PN-1-/- mice. Furthermore, physiological PN-1 disappearance and upregulation of the thrombin receptor PAR-1 (also known as F2R) during follicular regression in wild-type mice also correlate with such changes in DP cell characteristics. Our results indicate that control of thrombin signaling interferes with hair follicle dermal cells plasticity to regulate their function. 10.1242/jcs.018689 IS - 9 JF - J Cell Sci EP - 1443 TI - Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells VL - 121 SP - 1435 KW - dermal_sheath KW - hair_follicle KW - papilla KW - pi3k AU - Feutz, Anne-Catherine AU - Barrandon, Yann AU - Monard, Denis PY - 2008/05/01/ UR - http://dx.doi.org/10.1242/jcs.018689 ER -