Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis. Export

@article{citeulike:2907528, abstract = {We have investigated the function of TIE2/TEK receptor tyrosine kinase in the development of definitive hematopoiesis. In the vitelline artery at 9.5 days postcoitum (d.p.c.), TIE2+ hematopoietic cells aggregated and adhered to TIE2+ endothelial cells. Soluble TIE2-Fc chimeric protein inhibited the development of hematopoiesis and angiogenesis in the para-aortic splanchnopleural mesoderm (P-Sp) explant culture, and TIE2-deficient mice showed severely impaired definitive hematopoiesis. An in vitro study revealed that Angiopoietin-1 but not Angiopoietin-2 promoted the adhesion to fibronectin (FN) through integrins in TIE2-transfected cells and primary TIE2+ cells sorted from 9.5 d.p.c. P-Sp. Adhesion of TIE2+ cells induced by Angiopoietin-1 enhanced the proliferation of hematopoietic progenitor cells.}, address = {Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan.}, author = {Takakura, N. and Huang, X. L. and Naruse, T. and Hamaguchi, I. and Dumont, D. J. and Yancopoulos, G. D. and Suda, T.}, citeulike-article-id = {2907528}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/9846489}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=9846489}, issn = {1074-7613}, journal = {Immunity}, keywords = {agm, explants, p-sp}, month = {November}, number = {5}, pages = {677--686}, posted-at = {2008-06-19 15:55:21}, priority = {2}, title = {Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9846489}, volume = {9}, year = {1998} }

TY - JOUR ID - citeulike:2907528 L3 - citeulike-article-id:2907528 N2 - We have investigated the function of TIE2/TEK receptor tyrosine kinase in the development of definitive hematopoiesis. In the vitelline artery at 9.5 days postcoitum (d.p.c.), TIE2+ hematopoietic cells aggregated and adhered to TIE2+ endothelial cells. Soluble TIE2-Fc chimeric protein inhibited the development of hematopoiesis and angiogenesis in the para-aortic splanchnopleural mesoderm (P-Sp) explant culture, and TIE2-deficient mice showed severely impaired definitive hematopoiesis. An in vitro study revealed that Angiopoietin-1 but not Angiopoietin-2 promoted the adhesion to fibronectin (FN) through integrins in TIE2-transfected cells and primary TIE2+ cells sorted from 9.5 d.p.c. P-Sp. Adhesion of TIE2+ cells induced by Angiopoietin-1 enhanced the proliferation of hematopoietic progenitor cells. IS - 5 JF - Immunity SN - 1074-7613 AD - Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan. EP - 686 TI - Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis. VL - 9 SP - 677 KW - agm KW - explants KW - p-sp AU - Takakura, N AU - Huang, XL AU - Naruse, T AU - Hamaguchi, I AU - Dumont, DJ AU - Yancopoulos, GD AU - Suda, T PY - 1998/11// UR - http://view.ncbi.nlm.nih.gov/pubmed/9846489 ER -