Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo. Export

@article{citeulike:4237672, abstract = {In the present paper, we characterize an antibody, mAb BV13, directed to mouse vascular endothelial (VE)-cadherin, a major adhesive protein of interendothelial adherens junctions. When added to cultured endothelial cells, BV13 induces a redistribution of VE-cadherin from intercellular junctions. VE-cadherin redistribution did not change the localization of platelet endothelial cell adhesion molecule or tight junction markers such as zonula occludens 1, cingulin, and junctional adhesion molecule. Intravenous administration of mAb BV13 induced a concentration- and time-dependent increase in vascular permeability in heart and lungs. By electron microscopy, interstitial edema and accumulation of mixed types of inflammatory cells in heart and lungs were observed. Injection of (rhodamine-labeled) Ricinus communis I lectin showed focal spots of exposed basement membrane in the alveolar capillaries and in some larger pulmonary vessels. These data indicate that VE-cadherin is required for vascular integrity and normal organ functions.}, author = {Corada, M. and Mariotti, M. and Thurston, G. and Smith, K. and Kunkel, R. and Brockhaus, M. and Lampugnani, M. G. and Martin-Padura, I. and Stoppacciaro, A. and Ruco, L. and McDonald, D. M. and Ward, P. A. and Dejana, E.}, citeulike-article-id = {4237672}, citeulike-linkout-0 = {http://www.pnas.org/content/96/17/9815.full.abstract}, citeulike-linkout-1 = {http://www.pnas.org/content/96/17/9815.full.full.pdf}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/10449777}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=10449777}, day = {17}, issn = {0027-8424}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {antibody, ve-cadherin}, month = {August}, number = {17}, pages = {9815--9820}, posted-at = {2009-05-15 16:39:32}, priority = {2}, title = {Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo.}, url = {http://www.pnas.org/content/96/17/9815.full.abstract}, volume = {96}, year = {1999} }

TY - JOUR ID - citeulike:4237672 L3 - citeulike-article-id:4237672 N2 - In the present paper, we characterize an antibody, mAb BV13, directed to mouse vascular endothelial (VE)-cadherin, a major adhesive protein of interendothelial adherens junctions. When added to cultured endothelial cells, BV13 induces a redistribution of VE-cadherin from intercellular junctions. VE-cadherin redistribution did not change the localization of platelet endothelial cell adhesion molecule or tight junction markers such as zonula occludens 1, cingulin, and junctional adhesion molecule. Intravenous administration of mAb BV13 induced a concentration- and time-dependent increase in vascular permeability in heart and lungs. By electron microscopy, interstitial edema and accumulation of mixed types of inflammatory cells in heart and lungs were observed. Injection of (rhodamine-labeled) Ricinus communis I lectin showed focal spots of exposed basement membrane in the alveolar capillaries and in some larger pulmonary vessels. These data indicate that VE-cadherin is required for vascular integrity and normal organ functions. IS - 17 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 0027-8424 EP - 9820 TI - Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo. VL - 96 SP - 9815 KW - antibody KW - ve-cadherin AU - Corada, M AU - Mariotti, M AU - Thurston, G AU - Smith, K AU - Kunkel, R AU - Brockhaus, M AU - Lampugnani, MG AU - Martin-Padura, I AU - Stoppacciaro, A AU - Ruco, L AU - McDonald, DM AU - Ward, PA AU - Dejana, E PY - 1999/08/17/ UR - http://www.pnas.org/content/96/17/9815.full.abstract ER -