Lifecourse influences on health among British adults: Effects of region of residence in childhood and adulthood Export

@article{citeulike:4900260, abstract = {Background It has been suggested that early life exposures are important determinants of geographical variations in adult diseases. We examined inter-regional migrants in Britain to evaluate the relative importance of early and recent exposures for adult cardiorespiratory risk factors, mental ill-health and sensory function. Methods A total of 9023 persons born throughout England, Scotland and Wales during 1 week in 1958 were followed periodically through childhood into adulthood. At 44-45 years, height, body mass index (BMI), blood pressure (BP), glycosylated haemoglobin, total and high-density lipoprotein (HDL) cholesterol, triglycerides, fibrinogen, total immunoglobulin E (IgE), one-second forced expiratory volume (FEV1), hearing threshold at 4 kHz, visual impairment, symptoms of depression and anxiety, and chronic widespread pain were measured. Analysis of migration between 12 regions included 3125 cohort members who were examined in a region different to their birthplace. Results Height, BMI, diastolic BP (DBP), FEV1, log-transformed IgE and hearing threshold varied by region among non-migrants (each P < 0.05). Among inter-regional migrants, the spatial associations with current region, independent of birthplace, followed closely the geographical pattern shown among non-migrants for BMI, DBP and FEV1 (each P < 0.001). In contrast, of the 15 outcomes, only adult height was related to region of birth, after adjustment for region of examination (P = 0.002) Conclusions Although individual disease risk is predicted by early life factors, early exposures do not explain regional variations in cardiovascular and respiratory risk factors among middle-aged adults in Britain. Geographical inequalities in cardiorespiratory health are more strongly related to factors associated with region of examination that influence obesity, BP and ventilatory function. 10.1093/ije/dyl309}, author = {Strachan, David P. and Rudnicka, Alicja R. and Power, Chris and Shepherd, Peter and Fuller, Elizabeth and Davis, Adrian and Gibb, Ian and Kumari, Meena and Rumley, Ann and Macfarlane, Gary J. and Rahi, Jugnoo and Rodgers, Bryan and Stansfeld, Stephen}, citeulike-article-id = {4900260}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/ije/dyl309}, citeulike-linkout-1 = {http://ije.oxfordjournals.org/cgi/content/abstract/36/3/522}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17255346}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17255346}, doi = {10.1093/ije/dyl309}, journal = {Int. J. Epidemiol.}, keywords = {lifecourse}, month = {June}, number = {3}, pages = {522--531}, posted-at = {2009-06-19 05:51:04}, priority = {2}, title = {Lifecourse influences on health among British adults: Effects of region of residence in childhood and adulthood}, url = {http://dx.doi.org/10.1093/ije/dyl309}, volume = {36}, year = {2007} }

TY - JOUR ID - citeulike:4900260 L3 - citeulike-article-id:4900260 N2 - Background It has been suggested that early life exposures are important determinants of geographical variations in adult diseases. We examined inter-regional migrants in Britain to evaluate the relative importance of early and recent exposures for adult cardiorespiratory risk factors, mental ill-health and sensory function. Methods A total of 9023 persons born throughout England, Scotland and Wales during 1 week in 1958 were followed periodically through childhood into adulthood. At 44-45 years, height, body mass index (BMI), blood pressure (BP), glycosylated haemoglobin, total and high-density lipoprotein (HDL) cholesterol, triglycerides, fibrinogen, total immunoglobulin E (IgE), one-second forced expiratory volume (FEV1), hearing threshold at 4 kHz, visual impairment, symptoms of depression and anxiety, and chronic widespread pain were measured. Analysis of migration between 12 regions included 3125 cohort members who were examined in a region different to their birthplace. Results Height, BMI, diastolic BP (DBP), FEV1, log-transformed IgE and hearing threshold varied by region among non-migrants (each P < 0.05). Among inter-regional migrants, the spatial associations with current region, independent of birthplace, followed closely the geographical pattern shown among non-migrants for BMI, DBP and FEV1 (each P < 0.001). In contrast, of the 15 outcomes, only adult height was related to region of birth, after adjustment for region of examination (P = 0.002) Conclusions Although individual disease risk is predicted by early life factors, early exposures do not explain regional variations in cardiovascular and respiratory risk factors among middle-aged adults in Britain. Geographical inequalities in cardiorespiratory health are more strongly related to factors associated with region of examination that influence obesity, BP and ventilatory function. 10.1093/ije/dyl309 IS - 3 JF - Int. J. Epidemiol. EP - 531 TI - Lifecourse influences on health among British adults: Effects of region of residence in childhood and adulthood VL - 36 SP - 522 KW - lifecourse AU - Strachan, David AU - Rudnicka, Alicja AU - Power, Chris AU - Shepherd, Peter AU - Fuller, Elizabeth AU - Davis, Adrian AU - Gibb, Ian AU - Kumari, Meena AU - Rumley, Ann AU - Macfarlane, Gary AU - Rahi, Jugnoo AU - Rodgers, Bryan AU - Stansfeld, Stephen PY - 2007/06/01/ UR - http://dx.doi.org/10.1093/ije/dyl309 ER -