Life-course influences on health in British adults: effects of socio-economic position in childhood and adulthood Export

@article{citeulike:4900262, abstract = {Background Little evidence exists on the role of socio-economic position (SEP) in early life on adult disease other than for cardiovascular mortality; data is often retrospective. We assess whether childhood SEP influences disease risk in mid-life, separately from the effect of adult position, and establish how associations vary across multiple measures of disease risk. Methods Prospective follow-up to adulthood of all born in England, Scotland and Wales during 1 week in 1958, and with medical data at age 45 years (n = 9377). Outcomes include: blood pressure, body mass index (BMI), glycosylated haemoglobin (HbA1c), total and high density lipoprotein (HDL) cholesterol, triglycerides, fibrinogen, total immunoglobulin E (IgE), one-second forced expiratory volume (FEV1), hearing threshold (4 kHz), visual impairment, symptoms of depression and anxiety, chronic widespread pain. Results Social class in childhood was associated with blood pressure, BMI, HbA1c, HDL cholesterol, triglycerides, fibrinogen, FEV1, hearing threshold, depressive symptoms and chronic widespread pain, with a general trend of deteriorating health from class I to V. Adult social class was also associated with these measures. Mutually adjusted analyses of child and adult social class suggest that both contribute to disease risk in mid-life: in general, associations for childhood class were as strong as for adult class. Individuals with a manual class at both time-points tended to have the greatest health deficits in adulthood. Conclusions Adverse SEP in childhood is associated with a poorer health profile in mid-adulthood, independently of adult social position, and across diverse measures of disease risk and physical and mental functioning. 10.1093/ije/dyl310}, author = {Power, Chris and Atherton, Kate and Strachan, David P. and Shepherd, Peter and Fuller, Elizabeth and Davis, Adrian and Gibb, Ian and Kumari, Meena and Lowe, Gordon and Macfarlane, Gary J. and Rahi, Jugnoo and Rodgers, Bryan and Stansfeld, Stephen}, citeulike-article-id = {4900262}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/ije/dyl310}, citeulike-linkout-1 = {http://ije.oxfordjournals.org/cgi/content/abstract/36/3/532}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17255345}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17255345}, doi = {10.1093/ije/dyl310}, journal = {Int. J. Epidemiol.}, keywords = {lifecourse}, month = {June}, number = {3}, pages = {532--539}, posted-at = {2009-06-19 05:51:07}, priority = {2}, title = {Life-course influences on health in British adults: effects of socio-economic position in childhood and adulthood}, url = {http://dx.doi.org/10.1093/ije/dyl310}, volume = {36}, year = {2007} }

TY - JOUR ID - citeulike:4900262 L3 - citeulike-article-id:4900262 N2 - Background Little evidence exists on the role of socio-economic position (SEP) in early life on adult disease other than for cardiovascular mortality; data is often retrospective. We assess whether childhood SEP influences disease risk in mid-life, separately from the effect of adult position, and establish how associations vary across multiple measures of disease risk. Methods Prospective follow-up to adulthood of all born in England, Scotland and Wales during 1 week in 1958, and with medical data at age 45 years (n = 9377). Outcomes include: blood pressure, body mass index (BMI), glycosylated haemoglobin (HbA1c), total and high density lipoprotein (HDL) cholesterol, triglycerides, fibrinogen, total immunoglobulin E (IgE), one-second forced expiratory volume (FEV1), hearing threshold (4 kHz), visual impairment, symptoms of depression and anxiety, chronic widespread pain. Results Social class in childhood was associated with blood pressure, BMI, HbA1c, HDL cholesterol, triglycerides, fibrinogen, FEV1, hearing threshold, depressive symptoms and chronic widespread pain, with a general trend of deteriorating health from class I to V. Adult social class was also associated with these measures. Mutually adjusted analyses of child and adult social class suggest that both contribute to disease risk in mid-life: in general, associations for childhood class were as strong as for adult class. Individuals with a manual class at both time-points tended to have the greatest health deficits in adulthood. Conclusions Adverse SEP in childhood is associated with a poorer health profile in mid-adulthood, independently of adult social position, and across diverse measures of disease risk and physical and mental functioning. 10.1093/ije/dyl310 IS - 3 JF - Int. J. Epidemiol. EP - 539 TI - Life-course influences on health in British adults: effects of socio-economic position in childhood and adulthood VL - 36 SP - 532 KW - lifecourse AU - Power, Chris AU - Atherton, Kate AU - Strachan, David AU - Shepherd, Peter AU - Fuller, Elizabeth AU - Davis, Adrian AU - Gibb, Ian AU - Kumari, Meena AU - Lowe, Gordon AU - Macfarlane, Gary AU - Rahi, Jugnoo AU - Rodgers, Bryan AU - Stansfeld, Stephen PY - 2007/06/01/ UR - http://dx.doi.org/10.1093/ije/dyl310 ER -