Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging Export

@article{citeulike:5888530, abstract = {10.1073/pnas.081072698 Allostatic load (AL) has been proposed as a new conceptualization of cumulative biological burden exacted on the body through attempts to adapt to life's demands. Using a multisystem summary measure of AL, we evaluated its capacity to predict four categories of health outcomes, 7 years after a baseline survey of 1,189 men and women age 70\^{a}€“79. Higher baseline AL scores were associated with significantly increased risk for 7-year mortality as well as declines in cognitive and physical functioning and were marginally associated with incident cardiovascular disease events, independent of standard socio-demographic characteristics and baseline health status. The summary AL measure was based on 10 parameters of biological functioning, four of which are primary mediators in the cascade from perceived challenges to downstream health outcomes. Six of the components are secondary mediators reflecting primarily components of the metabolic syndrome (syndrome X). AL was a better predictor of mortality and decline in physical functioning than either the syndrome X or primary mediator components alone. The findings support the concept of AL as a measure of cumulative biological burden.}, author = {Seeman, Teresa E. and McEwen, Bruce S. and Rowe, John W. and Singer, Burton H.}, citeulike-article-id = {5888530}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.081072698}, citeulike-linkout-1 = {http://www.pnas.org/content/98/8/4770.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/98/8/4770.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/11287659}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=11287659}, day = {10}, doi = {10.1073/pnas.081072698}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {aging, allostatic, biological, load, risk}, month = {April}, number = {8}, pages = {4770--4775}, posted-at = {2009-10-05 09:16:54}, priority = {5}, title = {Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging}, url = {http://dx.doi.org/10.1073/pnas.081072698}, volume = {98}, year = {2001} }

TY - JOUR ID - citeulike:5888530 L3 - citeulike-article-id:5888530 N2 - 10.1073/pnas.081072698 Allostatic load (AL) has been proposed as a new conceptualization of cumulative biological burden exacted on the body through attempts to adapt to life's demands. Using a multisystem summary measure of AL, we evaluated its capacity to predict four categories of health outcomes, 7 years after a baseline survey of 1,189 men and women age 70–79. Higher baseline AL scores were associated with significantly increased risk for 7-year mortality as well as declines in cognitive and physical functioning and were marginally associated with incident cardiovascular disease events, independent of standard socio-demographic characteristics and baseline health status. The summary AL measure was based on 10 parameters of biological functioning, four of which are primary mediators in the cascade from perceived challenges to downstream health outcomes. Six of the components are secondary mediators reflecting primarily components of the metabolic syndrome (syndrome X). AL was a better predictor of mortality and decline in physical functioning than either the syndrome X or primary mediator components alone. The findings support the concept of AL as a measure of cumulative biological burden. IS - 8 JF - Proceedings of the National Academy of Sciences of the United States of America EP - 4775 TI - Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging VL - 98 SP - 4770 KW - aging KW - allostatic KW - biological KW - load KW - risk AU - Seeman, Teresa AU - McEwen, Bruce AU - Rowe, John AU - Singer, Burton PY - 2001/04/10/ UR - http://dx.doi.org/10.1073/pnas.081072698 ER -