Alternative activation of macrophages. Export

@article{citeulike:1621712, abstract = {The classical pathway of interferon-gamma-dependent activation of macrophages by T helper 1 (T(H)1)-type responses is a well-established feature of cellular immunity to infection with intracellular pathogens, such as Mycobacterium tuberculosis and HIV. The concept of an alternative pathway of macrophage activation by the T(H)2-type cytokines interleukin-4 (IL-4) and IL-13 has gained credence in the past decade, to account for a distinctive macrophage phenotype that is consistent with a different role in humoral immunity and repair. In this review, I assess the evidence in favour of alternative macrophage activation in the light of macrophage heterogeneity, and define its limits and relevance to a range of immune and inflammatory conditions.}, address = {Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. Christine.Holt@path.ox.ac.uk}, author = {Gordon, Siamon}, citeulike-article-id = {1621712}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nri978}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nri978}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/12511873}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=12511873}, doi = {10.1038/nri978}, issn = {1474-1733}, journal = {Nature reviews. Immunology}, keywords = {alternate, classic, m1, m2, macrophage}, month = {January}, number = {1}, pages = {23--35}, posted-at = {2008-06-06 10:41:32}, priority = {2}, title = {Alternative activation of macrophages.}, url = {http://dx.doi.org/10.1038/nri978}, volume = {3}, year = {2003} }

TY - JOUR ID - citeulike:1621712 L3 - citeulike-article-id:1621712 N2 - The classical pathway of interferon-gamma-dependent activation of macrophages by T helper 1 (T(H)1)-type responses is a well-established feature of cellular immunity to infection with intracellular pathogens, such as Mycobacterium tuberculosis and HIV. The concept of an alternative pathway of macrophage activation by the T(H)2-type cytokines interleukin-4 (IL-4) and IL-13 has gained credence in the past decade, to account for a distinctive macrophage phenotype that is consistent with a different role in humoral immunity and repair. In this review, I assess the evidence in favour of alternative macrophage activation in the light of macrophage heterogeneity, and define its limits and relevance to a range of immune and inflammatory conditions. IS - 1 JF - Nature reviews. Immunology SN - 1474-1733 AD - Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. Christine.Holt@path.ox.ac.uk EP - 35 TI - Alternative activation of macrophages. VL - 3 SP - 23 KW - alternate KW - classic KW - m1 KW - m2 KW - macrophage AU - Gordon, Siamon PY - 2003/01// UR - http://dx.doi.org/10.1038/nri978 ER -