Conformational change in substrate binding, catalysis and product release: an open and shut case? Export

@article{citeulike:363456, abstract = {The role of conformational change in substrate binding, catalysis and product release is reviewed for 11 enzymes, for which crystal structures are available for the apo, substrate- and product-bound states. The extent of global conformational changes is measured, and the movements of the functional regions involved in catalysis and ligand binding are compared to the rest of the structure. We find that most of these enzymes undergo relatively small amounts of conformational change and particularly small changes in catalytic residue geometry, usually less than 1 A. In some enzymes there is significant movement of the binding residues, usually on surface loops.}, address = {EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK. alexg@ebi.ac.uk}, author = {Gutteridge, A. and Thornton, J.}, citeulike-article-id = {363456}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.febslet.2004.03.067}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15165895}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15165895}, day = {1}, doi = {10.1016/j.febslet.2004.03.067}, issn = {0014-5793}, journal = {FEBS Lett}, keywords = {active\_sites, catalysis, conformational\_change, enzyme, reaction}, month = {June}, number = {1}, pages = {67--73}, posted-at = {2005-11-11 15:25:36}, priority = {2}, title = {Conformational change in substrate binding, catalysis and product release: an open and shut case?}, url = {http://dx.doi.org/10.1016/j.febslet.2004.03.067}, volume = {567}, year = {2004} }

TY - JOUR ID - citeulike:363456 L3 - citeulike-article-id:363456 N2 - The role of conformational change in substrate binding, catalysis and product release is reviewed for 11 enzymes, for which crystal structures are available for the apo, substrate- and product-bound states. The extent of global conformational changes is measured, and the movements of the functional regions involved in catalysis and ligand binding are compared to the rest of the structure. We find that most of these enzymes undergo relatively small amounts of conformational change and particularly small changes in catalytic residue geometry, usually less than 1 A. In some enzymes there is significant movement of the binding residues, usually on surface loops. IS - 1 JF - FEBS Lett SN - 0014-5793 AD - EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK. alexg@ebi.ac.uk EP - 73 TI - Conformational change in substrate binding, catalysis and product release: an open and shut case? VL - 567 SP - 67 KW - active_sites KW - catalysis KW - conformational_change KW - enzyme KW - reaction AU - Gutteridge, A AU - Thornton, J PY - 2004/06/01/ UR - http://dx.doi.org/10.1016/j.febslet.2004.03.067 ER -