Structural assignments to the Mycoplasma genitalium proteins show extensive gene duplications and domain rearrangements. Export

@article{Teichmann98, abstract = {The parasitic bacterium Mycoplasma genitalium has a small, reduced genome with close to a basic set of genes. As a first step toward determining the families of protein domains that form the products of these genes, we have used the multiple sequence programs PSI-BLAST and GEANFAMMER to match the sequences of the 467 gene products of M. genitalium to the sequences of the domains that form proteins of known structure [Protein Data Bank (PDB) sequences]. PDB sequences (274) match all of 106 M. genitalium sequences and some parts of another 85; thus, 41\% of its total sequences are matched in all or part. The evolutionary relationships of the PDB domains that match M. genitalium are described in the structural classification of proteins (SCOP) database. Using this information, we show that the domains in the matched M. genitalium sequences come from 114 superfamilies and that 58\% of them have arisen by gene duplication. This level of d...}, address = {Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom. sat@mrc-lmb.cam.ac.uk}, author = {Teichmann, S. A. and Park, J. and Chothia, C.}, citeulike-article-id = {388905}, editor = {1998/12/09}, journal = {Proc Natl Acad Sci U S A}, keywords = {annotation, gene\_duplication, m\_genitalium}, number = {25}, posted-at = {2005-11-11 16:23:16}, priority = {2}, title = {Structural assignments to the Mycoplasma genitalium proteins show extensive gene duplications and domain rearrangements.}, volume = {95}, year = {1998} }

TY - JOUR ID - Teichmann98 L3 - citeulike-article-id:388905 N2 - The parasitic bacterium Mycoplasma genitalium has a small, reduced genome with close to a basic set of genes. As a first step toward determining the families of protein domains that form the products of these genes, we have used the multiple sequence programs PSI-BLAST and GEANFAMMER to match the sequences of the 467 gene products of M. genitalium to the sequences of the domains that form proteins of known structure [Protein Data Bank (PDB) sequences]. PDB sequences (274) match all of 106 M. genitalium sequences and some parts of another 85; thus, 41\% of its total sequences are matched in all or part. The evolutionary relationships of the PDB domains that match M. genitalium are described in the structural classification of proteins (SCOP) database. Using this information, we show that the domains in the matched M. genitalium sequences come from 114 superfamilies and that 58\% of them have arisen by gene duplication. This level of d... IS - 25 JF - Proc Natl Acad Sci U S A AD - Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom. sat@mrc-lmb.cam.ac.uk TI - Structural assignments to the Mycoplasma genitalium proteins show extensive gene duplications and domain rearrangements. VL - 95 KW - annotation KW - gene_duplication KW - m_genitalium AU - Teichmann, SA AU - Park, J AU - Chothia, C A2 - 1998/12/09 PY - 1998/// ER -