Predicting enzyme function from protein sequence. Export

@article{citeulike:455565, abstract = {There are two main reasons to try to predict an enzyme's function from its sequence. The first is to identify the components and thus the functional capabilities of an organism, the second is to create enzymes with specific properties. Genomics, expression analysis, proteomics and metabonomics are largely directed towards understanding how information flows from DNA sequence to protein functions within an organism. This review focuses on information flow in the opposite direction: the applicability of what is being learned from natural enzymes to improve methods for catalyst design.}, address = {DNA 2.0, 1455 Adams Drive, Menlo Park, CA 94025, USA. minshull@dnatwopointo.com}, author = {Minshull, J. and Ness, J. E. and Gustafsson, C. and Govindarajan, S.}, citeulike-article-id = {455565}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cbpa.2005.02.003}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15811806}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15811806}, doi = {10.1016/j.cbpa.2005.02.003}, issn = {1367-5931}, journal = {Curr Opin Chem Biol}, keywords = {enzyme, function}, month = {April}, number = {2}, pages = {202--209}, posted-at = {2006-01-04 15:48:58}, priority = {5}, title = {Predicting enzyme function from protein sequence.}, url = {http://dx.doi.org/10.1016/j.cbpa.2005.02.003}, volume = {9}, year = {2005} }

TY - JOUR ID - citeulike:455565 L3 - citeulike-article-id:455565 N2 - There are two main reasons to try to predict an enzyme's function from its sequence. The first is to identify the components and thus the functional capabilities of an organism, the second is to create enzymes with specific properties. Genomics, expression analysis, proteomics and metabonomics are largely directed towards understanding how information flows from DNA sequence to protein functions within an organism. This review focuses on information flow in the opposite direction: the applicability of what is being learned from natural enzymes to improve methods for catalyst design. IS - 2 JF - Curr Opin Chem Biol SN - 1367-5931 AD - DNA 2.0, 1455 Adams Drive, Menlo Park, CA 94025, USA. minshull@dnatwopointo.com EP - 209 TI - Predicting enzyme function from protein sequence. VL - 9 SP - 202 KW - enzyme KW - function AU - Minshull, J AU - Ness, JE AU - Gustafsson, C AU - Govindarajan, S PY - 2005/04// UR - http://dx.doi.org/10.1016/j.cbpa.2005.02.003 ER -