The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Export

@article{citeulike:4503877, abstract = {Several subsets of Foxp3(+) regulatory T cells (T(reg) cells) work in concert to maintain immune homeostasis. However, the molecular bases underlying the phenotypic and functional diversity of T(reg) cells remain obscure. We show that in response to interferon-gamma, Foxp3(+) T(reg) cells upregulated the T helper type 1 (T(H)1)-specifying transcription factor T-bet. T-bet promoted expression of the chemokine receptor CXCR3 on T(reg) cells, and T-bet(+) T(reg) cells accumulated at sites of T(H)1 cell-mediated inflammation. Furthermore, T-bet expression was required for the homeostasis and function of T(reg) cells during type 1 inflammation. Thus, in a subset of CD4(+) T cells, the activities of the transcription factors Foxp3 and T-bet are overlaid, which results in T(reg) cells with unique homeostatic and migratory properties optimized for the suppression of T(H)1 responses in vivo.}, author = {Koch, Meghan A A. and Tucker-Heard, Glady's and Perdue, Nikole R R. and Killebrew, Justin R R. and Urdahl, Kevin B B. and Campbell, Daniel J J.}, citeulike-article-id = {4503877}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ni.1731}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ni.1731}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19412181}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19412181}, day = {3}, doi = {10.1038/ni.1731}, issn = {1529-2916}, journal = {Nature immunology}, keywords = {chemokine, tbet, transcriptionfactor, treg}, month = {May}, posted-at = {2009-05-12 03:44:08}, priority = {2}, title = {The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation.}, url = {http://dx.doi.org/10.1038/ni.1731}, year = {2009} }

TY - JOUR ID - citeulike:4503877 L3 - citeulike-article-id:4503877 N2 - Several subsets of Foxp3(+) regulatory T cells (T(reg) cells) work in concert to maintain immune homeostasis. However, the molecular bases underlying the phenotypic and functional diversity of T(reg) cells remain obscure. We show that in response to interferon-gamma, Foxp3(+) T(reg) cells upregulated the T helper type 1 (T(H)1)-specifying transcription factor T-bet. T-bet promoted expression of the chemokine receptor CXCR3 on T(reg) cells, and T-bet(+) T(reg) cells accumulated at sites of T(H)1 cell-mediated inflammation. Furthermore, T-bet expression was required for the homeostasis and function of T(reg) cells during type 1 inflammation. Thus, in a subset of CD4(+) T cells, the activities of the transcription factors Foxp3 and T-bet are overlaid, which results in T(reg) cells with unique homeostatic and migratory properties optimized for the suppression of T(H)1 responses in vivo. JF - Nature immunology SN - 1529-2916 TI - The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. KW - chemokine KW - tbet KW - transcriptionfactor KW - treg AU - Koch, Meghan A AU - Tucker-Heard, Glady's AU - Perdue, Nikole R AU - Killebrew, Justin R AU - Urdahl, Kevin B AU - Campbell, Daniel J PY - 2009/05/03/ UR - http://dx.doi.org/10.1038/ni.1731 ER -