Netrin-1 Is a Novel Myelin-Associated Inhibitor to Axon Growth Export

@article{citeulike:2329983, abstract = {We investigated the influence of the bifunctional guidance molecule netrin-1 on axonal growth in the injured adult spinal cord. In the adult, netrin-1 is expressed on mature oligodendrocytes, cells of the central canal, and the meninges. Netrin-1 protein in white matter is selectively enriched adjacent to paranodal loops of myelin in nodes of Ranvier. The repulsion-mediating netrin-1 uncoordinated-5 (UNC5) receptors are expressed by neurons of the corticospinal and rubrospinal projections, and by intrinsic neurons of the spinal cord, both before and after spinal cord injury. Neutralization of netrin-1 in myelin prepared from adult rat spinal cord using UNC5 receptor bodies increases neurite outgrowth from UNC5-expressing spinal motor neurons in vitro. Furthermore, axon regeneration is inhibited in a netrin-1-enriched zone, devoid of other myelin-associated inhibitors, within spinal cord lesion sites in vivo. We conclude that netrin-1 is a novel oligodendrocyte-associated inhibitor that can contribute to axonal growth failure after adult spinal cord injury. 10.1523/JNEUROSCI.4906-07.2008}, author = {Low, Karin and Culbertson, Maya and Bradke, Frank and Tessier-Lavigne, Marc and Tuszynski, Mark H.}, citeulike-article-id = {2329983}, citeulike-linkout-0 = {http://dx.doi.org/10.1523/JNEUROSCI.4906-07.2008}, citeulike-linkout-1 = {http://www.jneurosci.org/cgi/content/abstract/28/5/1099}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18234888}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18234888}, day = {30}, doi = {10.1523/JNEUROSCI.4906-07.2008}, journal = {J. Neurosci.}, keywords = {drg}, month = {January}, number = {5}, pages = {1099--1108}, posted-at = {2008-02-04 16:39:16}, priority = {2}, title = {Netrin-1 Is a Novel Myelin-Associated Inhibitor to Axon Growth}, url = {http://dx.doi.org/10.1523/JNEUROSCI.4906-07.2008}, volume = {28}, year = {2008} }

TY - JOUR ID - citeulike:2329983 L3 - citeulike-article-id:2329983 N2 - We investigated the influence of the bifunctional guidance molecule netrin-1 on axonal growth in the injured adult spinal cord. In the adult, netrin-1 is expressed on mature oligodendrocytes, cells of the central canal, and the meninges. Netrin-1 protein in white matter is selectively enriched adjacent to paranodal loops of myelin in nodes of Ranvier. The repulsion-mediating netrin-1 uncoordinated-5 (UNC5) receptors are expressed by neurons of the corticospinal and rubrospinal projections, and by intrinsic neurons of the spinal cord, both before and after spinal cord injury. Neutralization of netrin-1 in myelin prepared from adult rat spinal cord using UNC5 receptor bodies increases neurite outgrowth from UNC5-expressing spinal motor neurons in vitro. Furthermore, axon regeneration is inhibited in a netrin-1-enriched zone, devoid of other myelin-associated inhibitors, within spinal cord lesion sites in vivo. We conclude that netrin-1 is a novel oligodendrocyte-associated inhibitor that can contribute to axonal growth failure after adult spinal cord injury. 10.1523/JNEUROSCI.4906-07.2008 IS - 5 JF - J. Neurosci. EP - 1108 TI - Netrin-1 Is a Novel Myelin-Associated Inhibitor to Axon Growth VL - 28 SP - 1099 KW - drg AU - Low, Karin AU - Culbertson, Maya AU - Bradke, Frank AU - Tessier-Lavigne, Marc AU - Tuszynski, Mark PY - 2008/01/30/ UR - http://dx.doi.org/10.1523/JNEUROSCI.4906-07.2008 ER -