Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Export

@article{citeulike:5728212, abstract = {We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 cases and 7,848 controls), we replicated the established association with the apolipoprotein E (APOE) locus (most significant SNP, rs2075650, P = 1.8 x 10(-157)) and observed genome-wide significant association with SNPs at two loci not previously associated with the disease: at the CLU (also known as APOJ) gene (rs11136000, P = 1.4 x 10(-9)) and 5' to the PICALM gene (rs3851179, P = 1.9 x 10(-8)). These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86).}, author = {Harold, Denise and Abraham, Richard and Hollingworth, Paul and Sims, Rebecca and Gerrish, Amy and Hamshere, Marian L. and Pahwa, Jaspreet Singh S. and Moskvina, Valentina and Dowzell, Kimberley and Williams, Amy and Jones, Nicola and Thomas, Charlene and Stretton, Alexandra and Morgan, Angharad R. and Lovestone, Simon and Powell, John and Proitsi, Petroula and Lupton, Michelle K. and Brayne, Carol and Rubinsztein, David C. and Gill, Michael and Lawlor, Brian and Lynch, Aoibhinn and Morgan, Kevin and Brown, Kristelle S. and Passmore, Peter A. and Craig, David and McGuinness, Bernadette and Todd, Stephen and Holmes, Clive and Mann, David and Smith, A. David and Love, Seth and Kehoe, Patrick G. and Hardy, John and Mead, Simon and Fox, Nick and Rossor, Martin and Collinge, John and Maier, Wolfgang and Jessen, Frank and Sch\"{u}rmann, Britta and van den Bussche, Hendrik and Heuser, Isabella and Kornhuber, Johannes and Wiltfang, Jens and Dichgans, Martin and Fr\"{o}lich, Lutz and Hampel, Harald and H\"{u}ll, Michael and Rujescu, Dan and Goate, Alison M. and Kauwe, John S. and Cruchaga, Carlos and Nowotny, Petra and Morris, John C. and Mayo, Kevin and Sleegers, Kristel and Bettens, Karolien and Engelborghs, Sebastiaan and De Deyn, Peter P. and Van Broeckhoven, Christine and Livingston, Gill and Bass, Nicholas J. and Gurling, Hugh and McQuillin, Andrew and Gwilliam, Rhian and Deloukas, Panagiotis and Al-Chalabi, Ammar and Shaw, Christopher E. and Tsolaki, Magda and Singleton, Andrew B. and Guerreiro, Rita and M\"{u}hleisen, Thomas W. and N\"{o}then, Markus M. and Moebus, Susanne and J\"{o}ckel, Karl-Heinz H. and Klopp, Norman and Wichmann, H-Erich E. and Carrasquillo, Minerva M. and Pankratz, V. Shane and Younkin, Steven G. and Holmans, Peter A. and O'Donovan, Michael and Owen, Michael J. and Williams, Julie}, citeulike-article-id = {5728212}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ng.440}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ng.440}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19734902}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19734902}, day = {06}, doi = {10.1038/ng.440}, issn = {1546-1718}, journal = {Nature genetics}, keywords = {alzheimer, alzheimer\_association, gwas}, month = {October}, number = {10}, pages = {1088--1093}, posted-at = {2009-09-07 13:20:15}, priority = {2}, publisher = {Nature Publishing Group}, title = {Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.}, url = {http://dx.doi.org/10.1038/ng.440}, volume = {41}, year = {2009} }

TY - JOUR ID - citeulike:5728212 L3 - citeulike-article-id:5728212 N2 - We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 cases and 7,848 controls), we replicated the established association with the apolipoprotein E (APOE) locus (most significant SNP, rs2075650, P = 1.8 x 10(-157)) and observed genome-wide significant association with SNPs at two loci not previously associated with the disease: at the CLU (also known as APOJ) gene (rs11136000, P = 1.4 x 10(-9)) and 5' to the PICALM gene (rs3851179, P = 1.9 x 10(-8)). These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86). IS - 10 JF - Nature genetics SN - 1546-1718 EP - 1093 TI - Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. PB - Nature Publishing Group VL - 41 SP - 1088 KW - alzheimer KW - alzheimer_association KW - gwas AU - Harold, Denise AU - Abraham, Richard AU - Hollingworth, Paul AU - Sims, Rebecca AU - Gerrish, Amy AU - Hamshere, Marian AU - Pahwa, Jaspreet Singh AU - Moskvina, Valentina AU - Dowzell, Kimberley AU - Williams, Amy AU - Jones, Nicola AU - Thomas, Charlene AU - Stretton, Alexandra AU - Morgan, Angharad AU - Lovestone, Simon AU - Powell, John AU - Proitsi, Petroula AU - Lupton, Michelle AU - Brayne, Carol AU - Rubinsztein, David AU - Gill, Michael AU - Lawlor, Brian AU - Lynch, Aoibhinn AU - Morgan, Kevin AU - Brown, Kristelle AU - Passmore, Peter AU - Craig, David AU - McGuinness, Bernadette AU - Todd, Stephen AU - Holmes, Clive AU - Mann, David AU - Smith, David AU - Love, Seth AU - Kehoe, Patrick AU - Hardy, John AU - Mead, Simon AU - Fox, Nick AU - Rossor, Martin AU - Collinge, John AU - Maier, Wolfgang AU - Jessen, Frank AU - Schürmann, Britta AU - van den Bussche, Hendrik AU - Heuser, Isabella AU - Kornhuber, Johannes AU - Wiltfang, Jens AU - Dichgans, Martin AU - Frölich, Lutz AU - Hampel, Harald AU - Hüll, Michael AU - Rujescu, Dan AU - Goate, Alison AU - Kauwe, John AU - Cruchaga, Carlos AU - Nowotny, Petra AU - Morris, John AU - Mayo, Kevin AU - Sleegers, Kristel AU - Bettens, Karolien AU - Engelborghs, Sebastiaan AU - De Deyn, Peter AU - Van Broeckhoven, Christine AU - Livingston, Gill AU - Bass, Nicholas AU - Gurling, Hugh AU - McQuillin, Andrew AU - Gwilliam, Rhian AU - Deloukas, Panagiotis AU - Al-Chalabi, Ammar AU - Shaw, Christopher AU - Tsolaki, Magda AU - Singleton, Andrew AU - Guerreiro, Rita AU - Mühleisen, Thomas AU - Nöthen, Markus AU - Moebus, Susanne AU - Jöckel, Karl-Heinz AU - Klopp, Norman AU - Wichmann, H-Erich AU - Carrasquillo, Minerva AU - Pankratz, Shane AU - Younkin, Steven AU - Holmans, Peter AU - O'Donovan, Michael AU - Owen, Michael AU - Williams, Julie PY - 2009/10/06/ UR - http://dx.doi.org/10.1038/ng.440 ER -