Approaches to comparative sequence analysis: towards a functional view of vertebrate genomes. Export

@article{citeulike:2553413, abstract = {The comparison of genomic sequences is now a common approach to identifying and characterizing functional regions in vertebrate genomes. However, for theoretical reasons and because of practical issues, the generation of these data sets is non-trivial and can have many pitfalls. We are currently seeing an explosion of comparative sequence data, the benefits and limitations of which need to be disseminated to the scientific community. This Review provides a critical overview of the different types of sequence data that are available for analysis and of contemporary comparative sequence analysis methods, highlighting both their strengths and limitations. Approaches to determining the biological significance of constrained sequence are also explored.}, author = {Margulies, Elliott H. and Birney, Ewan}, citeulike-article-id = {2553413}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2185}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2185}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18347593}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18347593}, doi = {10.1038/nrg2185}, issn = {1471-0064}, journal = {Nature reviews. Genetics}, keywords = {general}, month = {April}, number = {4}, pages = {303--313}, posted-at = {2009-11-13 12:54:15}, priority = {2}, publisher = {Nature Publishing Group}, title = {Approaches to comparative sequence analysis: towards a functional view of vertebrate genomes.}, url = {http://dx.doi.org/10.1038/nrg2185}, volume = {9}, year = {2008} }

TY - JOUR ID - citeulike:2553413 L3 - citeulike-article-id:2553413 N2 - The comparison of genomic sequences is now a common approach to identifying and characterizing functional regions in vertebrate genomes. However, for theoretical reasons and because of practical issues, the generation of these data sets is non-trivial and can have many pitfalls. We are currently seeing an explosion of comparative sequence data, the benefits and limitations of which need to be disseminated to the scientific community. This Review provides a critical overview of the different types of sequence data that are available for analysis and of contemporary comparative sequence analysis methods, highlighting both their strengths and limitations. Approaches to determining the biological significance of constrained sequence are also explored. IS - 4 JF - Nature reviews. Genetics SN - 1471-0064 EP - 313 TI - Approaches to comparative sequence analysis: towards a functional view of vertebrate genomes. PB - Nature Publishing Group VL - 9 SP - 303 KW - general AU - Margulies, Elliott AU - Birney, Ewan PY - 2008/04// UR - http://dx.doi.org/10.1038/nrg2185 ER -