Antigenic Variation in Plasmodium falciparum Export

@article{citeulike:3245213, abstract = {The persistence of the human malaria parasite Plasmodium falciparum during blood stage proliferation in its host depends on the successive expression of variant molecules at the surface of infected erythrocytes. This variation is mediated by the differential control of a family of surface molecules termed PfEMP1 encoded by approximately 60 var genes. Each individual parasite expresses a single var gene at a time, maintaining all other members of the family in a transcriptionally silent state. PfEMP1/var enables parasitized erythrocytes to adhere within the microvasculature, resulting in severe disease. This review highlights key regulatory mechanisms thought to be critical for monoallelic expression of var genes. Antigenic variation is orchestrated by epigenetic factors including monoallelic var transcription at separate spatial domains at the nuclear periphery, differential histone marks on otherwise identical var genes, and var silencing mediated by telomeric heterochromatin. In addition, controversies surrounding var genetic elements in antigenic variation are discussed.}, author = {Scherf, Artur and Jose and Riviere, Loic}, citeulike-article-id = {3245213}, citeulike-linkout-0 = {http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.micro.61.080706.093134}, citeulike-linkout-1 = {http://dx.doi.org/10.1146/annurev.micro.61.080706.093134}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18785843}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18785843}, citeulike-linkout-4 = {http://dx.doi.org/http://dx.doi.org/10.1146/annurev.micro.61.080706.093134}, citeulike-linkout-5 = {http://dx.doi.org/10.1146/annurev.micro.61.080706.093134}, doi = {10.1146/annurev.micro.61.080706.093134}, issn = {0066-4227}, journal = {Annual Review of Microbiology}, keywords = {pseudogenes}, number = {1}, pages = {445--470}, posted-at = {2008-09-12 12:54:52}, priority = {2}, title = {Antigenic Variation in Plasmodium falciparum}, url = {http://dx.doi.org/10.1146/annurev.micro.61.080706.093134}, volume = {62}, year = {2008} }

TY - JOUR ID - citeulike:3245213 L3 - citeulike-article-id:3245213 N2 - The persistence of the human malaria parasite Plasmodium falciparum during blood stage proliferation in its host depends on the successive expression of variant molecules at the surface of infected erythrocytes. This variation is mediated by the differential control of a family of surface molecules termed PfEMP1 encoded by approximately 60 var genes. Each individual parasite expresses a single var gene at a time, maintaining all other members of the family in a transcriptionally silent state. PfEMP1/var enables parasitized erythrocytes to adhere within the microvasculature, resulting in severe disease. This review highlights key regulatory mechanisms thought to be critical for monoallelic expression of var genes. Antigenic variation is orchestrated by epigenetic factors including monoallelic var transcription at separate spatial domains at the nuclear periphery, differential histone marks on otherwise identical var genes, and var silencing mediated by telomeric heterochromatin. In addition, controversies surrounding var genetic elements in antigenic variation are discussed. IS - 1 JF - Annual Review of Microbiology SN - 0066-4227 EP - 470 TI - Antigenic Variation in Plasmodium falciparum VL - 62 SP - 445 KW - pseudogenes AU - Scherf, Artur AU - Jose AU - Riviere, Loic PY - 2008/// UR - http://dx.doi.org/10.1146/annurev.micro.61.080706.093134 ER -